Gene: DAB2IP
Official Full Name: DAB2 interacting proteinprovided by HGNC
Gene Summary: DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed 15386433]).[supplied by OMIM, May 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO08310 | DAB2IP Knockout cell line (HeLa) | Human | DAB2IP | 1:3~1:6 | Negative | Online Inquiry |
KO08311 | DAB2IP Knockout cell line (HCT 116) | Human | DAB2IP | 1:2~1:4 | Negative | Online Inquiry |
KO08312 | DAB2IP Knockout cell line (HEK293) | Human | DAB2IP | 1:3~1:6 | Negative | Online Inquiry |
KO08313 | DAB2IP Knockout cell line (A549) | Human | DAB2IP | 1:3~1:4 | Negative | Online Inquiry |
DAB2IP Gene Knockout Cell Lines are specialized cellular models that have been engineered to lack the DAB2IP gene, a critical regulator in various cellular processes, including apoptosis, proliferation, and tumor progression. This product serves as an indispensable tool for researchers exploring the molecular underpinnings of diseases, particularly cancer. The knockout mechanism involves CRISPR/Cas9 technology, which allows for precise edits to the genome, effectively silencing the DAB2IP gene, thereby elucidating its functional relevance in cellular signaling pathways.
The key functions of DAB2IP Gene Knockout Cell Lines include the ability to study the cellular response to stress, changes in tumorigenic potential, and the mechanisms of resistance to therapies. By observing the behaviors of these cell lines in vitro, researchers can derive insights into critical signaling cascades influenced by DAB2IP, which may lead to novel therapeutic interventions. Its applications extend from basic biological research to more translational efforts aimed at improving cancer treatment strategies and understanding metastasis.
One of the unique selling points of DAB2IP Gene Knockout Cell Lines is their specificity and reproducibility compared to traditional gene knockdown methods, such as siRNA, which may not achieve complete gene inhibition. Additionally, CRISPR technology ensures a permanent genetic modification, enabling longitudinal studies that are vital for exploring the role of DAB2IP in chronic conditions.
These cell lines offer significant value to researchers and clinicians, enhancing the capacity to develop targeted therapies and personalize medicine approaches in oncology. With DAB2IP Gene Knockout Cell Lines, users can accelerate their research with confidence, building on a solid foundation of reproducible and relevant experimental data.
Our company is a leader in providing high-quality biological products and innovative tools that support scientific research and development, underscoring our commitment to advancing the frontiers of biomedical science. With expertise in genetic engineering and cellular models, we empower researchers to unlock new discoveries and drive breakthroughs in medical science.
Please note that all services are for research use only. Not intended for any clinical use.
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