Gene: Cs
Official Full Name: citrate synthaseprovided by MGI
Gene Summary: The protein encoded by this gene is a central metabolic pathway enzyme, catalyzing the first step of the tricarboxylic acid cycle in which acetyl coenzyme A and oxaloacetate are converted to citrate and coenzyme A. This enzyme is found in nearly all cells capable of oxidative metabolism. This protein is nuclear encoded and transported into the mitochondrial matrix, where the mature form is found. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01244 | Cs Knockout cell line (AML12) | Mouse | Cs | 1:3~1:6 | Negative | Online Inquiry |
Cs Gene Knockout Cell Lines are genetically manipulated cell lines that have undergone a precise deletion of specific genes through targeted gene editing techniques such as CRISPR/Cas9. These cell lines serve as invaluable experimental models for studying gene function, cellular mechanisms, and the implications of gene loss in various biological and pathological contexts. By providing a controlled environment where specific genes are absent, researchers can elucidate the phenotypic consequences and molecular pathways that are affected by such modifications.
The primary mechanism of action involves the introduction of a guide RNA, which directs the Cas9 nuclease to the target gene sequence, leading to double-strand breaks. The cell’s repair mechanisms then attempt to fix these breaks, often resulting in insertions or deletions that disrupt the gene's coding sequence, ultimately yielding a knockout phenotype. This method allows for high specificity and efficiency in generating knockout models that are crucial for understanding gene function in both developmental biology and disease states.
In the realm of scientific research and clinical applications, Cs Gene Knockout Cell Lines are essential for drug discovery, biomarker identification, and the development of targeted therapies. These models enable researchers to simulate disease states that are directly relevant to human health, facilitating the exploration of novel therapeutic interventions and the investigation of genetic contributions to complex disorders.
The unique selling points of Cs Gene Knockout Cell Lines include their customizable nature, rapid generation times, and the ability to create stable knockouts that maintain the genomic integrity necessary for long-term studies. Compared to conventional knockout techniques like homologous recombination, these cell lines offer a more efficient and streamlined approach for researchers seeking reliable results.
For researchers and clinicians, investing in Cs Gene Knockout Cell Lines means gaining access to advanced tools that enhance experimental rigor and reduce time-to-results in critical investigations. With a focus on quality and precision, our company specializes in providing innovative biological products that meet the rigorous demands of modern research. Our expertise in gene editing technologies ensures that you receive cell lines of the highest caliber to support your groundbreaking work.
Please note that all services are for research use only. Not intended for any clinical use.
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