Gene: Cd180
Official Full Name: CD180 antigenprovided by MGI
Gene Summary: Acts upstream of or within B cell proliferation involved in immune response; cellular response to lipopolysaccharide; and positive regulation of lipopolysaccharide-mediated signaling pathway. Predicted to be located in mitotic spindle; nuclear lumen; and plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Orthologous to human CD180 (CD180 molecule). [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO01201 | Cd180 Knockout cell line(RAW 264.7) | Mouse | Cd180 | 1:2-1:3 | Negative | Online Inquiry |
Cd180 Gene Knockout Cell Lines represent a significant advancement in the study of immune responses and cellular signaling pathways. These cell lines are engineered to have a targeted deletion of the Cd180 gene, which encodes the toll-like receptor 1 (TLR1) that plays a pivotal role in the innate immune system by recognizing pathogen-associated molecular patterns. By removing the Cd180 gene, these cell lines allow researchers to investigate the mechanisms of immune activation or suppression and to elucidate the role of TLR1 in various diseases, including autoimmune disorders and infections.
The key function of Cd180 Gene Knockout Cell Lines is their ability to provide a controlled environment for studying specific immune responses. By utilizing CRISPR-Cas9 technology for precise genome editing, these cell lines maintain high specificity, allowing for reliable data regarding the role of TLR1 in inflammatory responses and cell signaling. Researchers can perform functional assays, surface marker analysis, and cytokine profiling to assess the immune response in various experimental conditions.
In scientific research, these knockout cell lines are invaluable for unraveling complex immune signaling pathways and developing novel therapeutic approaches. Their use can lead to a better understanding of immune tolerance, chronic inflammation, and the development of immune-related therapies. In clinical settings, insights gained can potentially facilitate the development of targeted immunotherapies, leading to more effective treatments for a range of diseases.
Compared to alternatives, Cd180 Gene Knockout Cell Lines offer the advantage of a well-characterized model system that ensures reproducibility of results and reduces experimental variability. They are particularly useful in high-throughput screening scenarios for drug discovery and validation, providing a robust platform that enhances the accuracy of findings.
For researchers and clinicians focused on immunology and therapeutic development, the Cd180 Gene Knockout Cell Lines are an indispensable tool. Their precision-engineered design combined with their broad applicability in research solidifies their position as a premier product in the field.
Our company specializes in providing high-quality biological products tailored to meet the evolving needs of the scientific community. With a commitment to excellence and innovation, we ensure that our offerings, like the Cd180 Gene Knockout Cell Lines, empower researchers to reach new scientific frontiers.
Please note that all services are for research use only. Not intended for any clinical use.
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