Gene: CYTH1
Official Full Name: cytohesin 1provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This gene is highly expressed in natural killer and peripheral T cells, and regulates the adhesiveness of integrins at the plasma membrane of lymphocytes. A pseudogene of this gene has been defined on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO07699 | CYTH1 Knockout cell line (HeLa) | Human | CYTH1 | 1:3~1:6 | Negative | Online Inquiry |
KO07700 | CYTH1 Knockout cell line (HCT 116) | Human | CYTH1 | 1:2~1:4 | Negative | Online Inquiry |
KO07701 | CYTH1 Knockout cell line (HEK293) | Human | CYTH1 | 1:3~1:6 | Negative | Online Inquiry |
KO07702 | CYTH1 Knockout cell line (A549) | Human | CYTH1 | 1:3~1:4 | Negative | Online Inquiry |
CYTH1 Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to facilitate the study of the CYTH1 gene, known for its involvement in cellular signaling and membrane interactions. This product provides researchers with a crucial tool for investigating the roles of CYTH1 in various biological processes, including cell proliferation, differentiation, and apoptosis.
The key function of CYTH1 Gene Knockout Cell Lines lies in their ability to express a complete absence of the CYTH1 protein. This is achieved through the application of CRISPR-Cas9 gene editing technology, which allows for precise modifications in the genetic material of the cell line. By using these knockout lines, researchers can efficiently elucidate the gene's function, assess its involvement in specific pathways, and explore downstream effects when it is absent.
The scientific importance of CYTH1 Gene Knockout Cell Lines extends to various research and clinical applications. They empower researchers in fields such as cancer biology, neurobiology, and immunology by enabling the investigation of disease mechanisms associated with aberrations in CYTH1. Furthermore, these cell lines can serve as valuable models for drug screening and the development of therapeutic strategies targeting related pathways.
One of the unique advantages of CYTH1 Gene Knockout Cell Lines is their high specificity and reproducibility, compared to alternative approaches that may involve partial knockdown or off-target effects. This specificity allows for more reliable results, facilitating the advancement of research projects and clinical studies.
For researchers and clinicians seeking to unravel the complexities of gene function and disease mechanisms, CYTH1 Gene Knockout Cell Lines represent a valuable addition to their toolkit. They provide an efficient platform for hypothesis testing and experimental validation, driving forward the understanding of cellular behavior in health and disease.
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Please note that all services are for research use only. Not intended for any clinical use.
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