Gene: CYGB
Official Full Name: cytoglobinprovided by HGNC
Gene Summary: This gene encodes a globin protein found in vertebrate cells. The encoded protein is described as a hexacoordinate hemoglobin which binds ligand differently from the pentacoordinate hemoglobins involved in oxygen transport, and may be involved in protection during oxidative stress. This gene is located on chromosome 17 in the same region as a retinal gene which is mutated in progressive rod-cone degeneration, but in the opposite orientation. [provided by RefSeq, Jan 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO30780 | CYGB Knockout cell line (A549) | Human | CYGB | 1:3~1:4 | Negative | Online Inquiry |
CYGB Gene Knockout Cell Lines are genetically modified cell lines in which the cytochrome b558 gene (CYGB) has been selectively inactivated. The CYGB gene encodes for a heme-containing protein influential in various cellular processes, including oxygen transport, regulation of reactive oxygen species, and modulation of cellular signaling pathways. These knockout cell lines have been engineered using CRISPR/Cas9 technology, providing a precise and efficient mechanism for gene targeting, thus facilitating the study of CYGB's role in physiological and pathological contexts.
The primary function of CYGB Gene Knockout Cell Lines lies in their ability to help researchers dissect the biological functions associated with the CYGB gene. By observing the phenotypic consequences of CYGB loss, scientists can elucidate its involvement in disease mechanisms, particularly in cancer biology, neurodegenerative diseases, and cardiovascular dysfunction. The knockout model allows for controlled experimentation, enabling the exploration of potential therapeutic interventions, drug responses, and cellular behavior under various conditions.
Scientifically, these cell lines serve as a critical tool in research and clinical applications, particularly in understanding how altered CYGB expression can impact tumor progression or cellular oxidative stress response. They are invaluable for screening new pharmaceuticals or evaluating potential gene therapy approaches.
The advantages of utilizing CYGB Gene Knockout Cell Lines include their high specificity and reproducibility compared to alternative methods such as pharmacological inhibition or transient knockdown strategies. These models provide a stable and long-term system that better mimics in vivo conditions, allowing for more applicable findings to clinical scenarios.
For researchers and clinicians focused on disease mechanisms, cell signaling, and drug discovery, these knockout cell lines present immense value. They empower users to generate reliable data that can lead to breakthroughs in therapeutic strategies and biomarker identification.
Our company stands at the forefront of genetic research, committed to delivering high-quality biological models that drive innovation in life sciences. With extensive expertise in gene editing technologies, we are equipped to support your research needs and advance your findings in the field of medical science.
Please note that all services are for research use only. Not intended for any clinical use.
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