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CYBRD1 Knockout Cell Lines

Gene: CYBRD1

Official Full Name: cytochrome b reductase 1provided by HGNC

Gene Summary: This gene is a member of the cytochrome b(561) family that encodes an iron-regulated protein. It highly expressed in the duodenal brush border membrane. It has ferric reductase activity and is believed to play a physiological role in dietary iron absorption. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18453 CYBRD1 Knockout cell line (HeLa) Human CYBRD1 1:3~1:6 Negative Online Inquiry
KO18454 CYBRD1 Knockout cell line (HCT 116) Human CYBRD1 1:2~1:4 Negative Online Inquiry
KO18455 CYBRD1 Knockout cell line (HEK293) Human CYBRD1 1:3~1:6 Negative Online Inquiry
KO18456 CYBRD1 Knockout cell line (A549) Human CYBRD1 1:3~1:4 Negative Online Inquiry

Background

CYBRD1 Gene Knockout Cell Lines are precisely engineered cellular models designed to investigate the role of the CYBRD1 gene, which is implicated in iron metabolism and cellular redox balance. These knockout cell lines provide researchers with a powerful tool to study the gene's functional contributions, particularly in the context of disorders related to iron homeostasis, such as anemia and neurodegenerative diseases.

The primary mechanism of these cell lines involves the complete disruption of CYBRD1 gene expression, achieved through the use of CRISPR/Cas9 technology. This gene-editing approach enables the targeted deletion of the CYBRD1 locus, creating a specific and stable cell line devoid of the protein product. By eliminating CYBRD1, researchers can directly observe changes in cellular processes, including iron uptake, reactive oxygen species (ROS) production, and overall metabolic pathways. Consequently, these cell lines serve as ideal models for elucidating the pathophysiological roles that this gene may play in various diseases.

The scientific importance of CYBRD1 Gene Knockout Cell Lines extends to both research and clinical settings. They are invaluable for drug discovery and testing, allowing for the identification of potential therapeutics that could modulate iron metabolism. In addition, these cell lines facilitate the understanding of the genetic basis of iron-related conditions, thereby driving advancements in diagnostic and treatment strategies.

One of the specific advantages of using CYBRD1 Gene Knockout Cell Lines lies in their precision. Unlike other traditional cell lines, which may have variable expression levels of target genes, these knockout models offer reproducibility and consistency in studies, leading to more reliable data. Furthermore, our cell lines are rigorously validated, ensuring high-performance metrics that exceed those of alternative products in the market.

For researchers and clinicians looking to deepen their understanding of iron metabolism and its implications in human health, our CYBRD1 Gene Knockout Cell Lines represent an essential addition to their experimental toolkit. Our company has a rich history of innovation in biological products, backed by extensive knowledge in gene editing technologies. By choosing our product, you gain not only superior models for your research but also access to our expertise in supporting your projects effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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