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CUL5 Knockout Cell Lines

Gene: CUL5

Official Full Name: cullin 5provided by HGNC

Gene Summary: Enables ubiquitin ligase complex scaffold activity and ubiquitin protein ligase binding activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process and protein K11-linked ubiquitination. Located in site of DNA damage. Part of Cul5-RING ubiquitin ligase complex. Is active in nucleus. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34333 CUL5 Knockout cell line (HeLa) Human CUL5 1:3~1:6 Negative Online Inquiry
KO34334 CUL5 Knockout cell line (HCT 116) Human CUL5 1:2~1:4 Negative Online Inquiry
KO34335 CUL5 Knockout cell line (HEK293) Human CUL5 1:3~1:6 Negative Online Inquiry
KO34336 CUL5 Knockout cell line (A549) Human CUL5 1:3~1:4 Negative Online Inquiry

Background

CUL5 Gene Knockout Cell Lines represent a cutting-edge biotechnological advancement used to study the critical role of the CUL5 gene, which encodes a component of the Cullin-RING ligase complex implicated in ubiquitin-mediated protein degradation. These specially engineered cell lines enable researchers to knock out the CUL5 gene, providing an invaluable tool for elucidating its functions in various cellular processes, including cell proliferation, signaling pathways, and apoptosis. By creating a loss-of-function model, scientists can investigate the downstream effects on gene expression and protein interactions, offering insights into the underlying mechanisms of diseases such as cancer and viral infections.

The primary function of CUL5 Gene Knockout Cell Lines hinges on their ability to mimic a state of gene inactivation, thus facilitating the exploration of cellular behaviors that are otherwise masked by the presence of the wild-type gene. The knockout mechanism is accomplished using advanced genome editing techniques, such as CRISPR-Cas9, which ensures precise, efficient, and reproducible gene editing. This specificity not only reduces off-target effects but also allows for comprehensive analyses of the CUL5 gene's role in various physiological and pathological contexts.

From a scientific perspective, these knockout cell lines are pivotal in research settings that aim to elucidate the molecular dynamics associated with ubiquitin signaling pathways. They have broad applications in drug discovery, genetic studies, and therapeutic developments, further bridging the gap between fundamental research and clinical applications. With the growing interest in targeted therapies and precision medicine, understanding the role of the CUL5 gene is more pertinent than ever.

What sets CUL5 Gene Knockout Cell Lines apart from alternative models is their robust validation and characterizations, which ensure consistent performance in experimental setups. Researchers can achieve greater reproducibility and reliability in their findings, ultimately leading to enhanced experimental rigor. Furthermore, these cell lines facilitate studies on the host-pathogen interactions, aiding in the development of novel therapeutics against viral diseases.

In summary, for researchers and clinicians seeking reliable and efficient tools for genetic studies, CUL5 Gene Knockout Cell Lines offer an unparalleled resource. At [Your Company Name], we pride ourselves on our extensive expertise in providing high-quality biological products tailored to the specific needs of the scientific community. Our commitment to innovation and excellence ensures that you have access to the best tools necessary for advancing your research.

Please note that all services are for research use only. Not intended for any clinical use.

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