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CUEDC2 Knockout Cell Lines

Gene: CUEDC2

Official Full Name: CUE domain containing 2provided by HGNC

Gene Summary: Predicted to enable ubiquitin binding activity. Acts upstream of or within negative regulation of cytokine production involved in inflammatory response and negative regulation of macrophage cytokine production. Located in cytosol; nuclear membrane; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18477 CUEDC2 Knockout cell line (HeLa) Human CUEDC2 1:3~1:6 Negative Online Inquiry
KO18478 CUEDC2 Knockout cell line (HCT 116) Human CUEDC2 1:2~1:4 Negative Online Inquiry
KO18479 CUEDC2 Knockout cell line (HEK293) Human CUEDC2 1:3~1:6 Negative Online Inquiry
KO18480 CUEDC2 Knockout cell line (A549) Human CUEDC2 1:3~1:4 Negative Online Inquiry

Background

CUEDC2 Gene Knockout Cell Lines are genetically engineered cell models that enable researchers to investigate the functional roles of the CUEDC2 gene in various biological processes. CUEDC2 (Cellular Ubiquitin-Dependent Protein Degradation 2) is critical for cell cycle regulation and transcriptional control, making these knockout cell lines valuable tools for studying both fundamental cellular mechanisms and disease pathways.

The primary function of these cell lines is to enable the observation of phenotypic changes resulting from the loss of CUEDC2 expression. By utilizing CRISPR/Cas9 technology for precise gene editing, these knockout models allow researchers to evaluate the downstream effects of CUEDC2 depletion on cellular proliferation, apoptosis, and response to stressors. The mechanistic insight gained from these studies can illuminate the gene's role in oncogenesis, neurodegeneration, and other pathologies associated with dysregulated protein degradation pathways.

The scientific importance of CUEDC2 Gene Knockout Cell Lines is underscored by their application in both basic and applied research settings. These models facilitate the exploration of therapeutic targets for drug development, particularly in cancer research where CUEDC2 has been implicated in tumorigenesis. This can lead to innovative treatment strategies and enhance our understanding of cellular resilience and vulnerabilities.

Compared to alternative models, the CUEDC2 Gene Knockout Cell Lines provide a more robust and specific investigation of CUEDC2's function, as they present a complete absence of the gene rather than merely downregulation through siRNA or other methods. This precision ensures that researchers can attribute observed effects directly to CUEDC2 without confounding variables.

For researchers and clinicians focused on the molecular underpinnings of diseases, the CUEDC2 Gene Knockout Cell Lines represent an essential resource for advancing knowledge and therapeutic intervention. Our company specializes in the development of high-quality genetic models, ensuring reliability and reproducibility in scientific studies. With our commitment to empowering groundbreaking research, the CUEDC2 Gene Knockout Cell Lines stand as a testament to our expertise and dedication to advancing the frontiers of biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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