Gene: CTSL
Official Full Name: cathepsin Lprovided by HGNC
Gene Summary: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Additionally, this protein cleaves the S1 subunit of the SARS-CoV-2 spike protein, which is necessary for entry of the virus into the cell. [provided by RefSeq, Aug 2020]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO09906 | CTSL Knockout cell line (HeLa) | Human | CTSL | 1:3~1:6 | Negative | Online Inquiry |
KO09907 | CTSL Knockout cell line (HCT 116) | Human | CTSL | 1:2~1:4 | Negative | Online Inquiry |
KO09908 | CTSL Knockout cell line (HEK293) | Human | CTSL | 1:3~1:6 | Negative | Online Inquiry |
KO09909 | CTSL Knockout cell line (A549) | Human | CTSL | 1:3~1:4 | Negative | Online Inquiry |
CTSL Gene Knockout Cell Lines represent a cutting-edge biological tool designed for advanced research in cellular and molecular biology. These genetically engineered cell lines have undergone a targeted mutation that inactivates the cathepsin L gene (CTSL), a cysteine protease involved in various physiological processes, including protein degradation, immune response, and tumor progression. By knocking out the CTSL gene, researchers can investigate the specific roles that this protease plays in cellular functions and disease mechanisms.
The primary function of CTSL Gene Knockout Cell Lines is to elucidate the biological pathways influenced by cathepsin L. By comparing these knockout lines with wild-type counterparts, scientists can analyze changes in cellular behavior, proteomic profiles, and signaling pathways. This allows for a deeper understanding of disease states, particularly those related to cancer and autoimmune disorders, where cathepsin L has been implicated. Furthermore, these cell lines can serve as a reliable platform for drug discovery, enabling scientists to explore potential therapeutic interventions that target proteolytic pathways.
Scientifically, these products offer tremendous value in both academic and clinical research settings. They facilitate functional analyses of specific genes and proteins, potentially leading to breakthroughs in understanding complex diseases. Unlike traditional tools, CTSL Gene Knockout Cell Lines provide a clean genetic background which minimizes confounding effects, thus enhancing the reproducibility of experimental results.
The advantages of using CTSL Gene Knockout Cell Lines extend beyond their specificity; they are also characterized by ease of use and adaptability in varied laboratory environments. This flexibility, combined with their capability to produce high-fidelity data, sets them apart from alternative models, such as transient transfection approaches or animal models, which can be more time-consuming and labor-intensive.
For researchers and clinicians, the CTSL Gene Knockout Cell Lines represent an invaluable resource that can drive innovation in disease research and therapeutic development. By integrating advanced genetic engineering with robust experimental design, these cell lines offer a pathway toward enhanced understanding of disease mechanisms and the identification of novel treatment strategies.
As a leader in the field of biological products, our company is committed to providing high-quality research tools backed by extensive expertise in cellular biology, ensuring that our customers have access to the most reliable and cutting-edge innovations for their scientific endeavors.
Please note that all services are for research use only. Not intended for any clinical use.
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