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CTBP2 Knockout Cell Lines

Gene: CTBP2

Official Full Name: C-terminal binding protein 2provided by HGNC

Gene Summary: This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11809 CTBP2 Knockout cell line (HeLa) Human CTBP2 1:3~1:6 Negative Online Inquiry
KO11810 CTBP2 Knockout cell line (HCT 116) Human CTBP2 1:2~1:4 Negative Online Inquiry
KO11811 CTBP2 Knockout cell line (HEK293) Human CTBP2 1:3~1:6 Negative Online Inquiry
KO11812 CTBP2 Knockout cell line (A549) Human CTBP2 1:3~1:4 Negative Online Inquiry

Background

CTBP2 Gene Knockout Cell Lines are genetically modified cell lines designed to specifically eliminate the expression of the CTBP2 gene, a crucial component in cellular signaling pathways and development. Through the application of CRISPR-Cas9 technology, these cell lines have been engineered to disrupt CTBP2 gene function, allowing researchers to study its role in cellular processes such as proliferation, differentiation, and apoptosis in various biological contexts.

The mechanism behind the CTBP2 knockout involves targeted double-strand breaks in the genome, which are subsequently repaired through non-homologous end joining. This process leads to frameshift mutations that effectively silence the gene. Researchers utilizing these knockout cell lines gain insights into the molecular pathways that involve CTBP2, particularly its interaction with transcription factors and involvement in cancer progression and neurodevelopmental disorders.

The scientific importance of CTBP2 Gene Knockout Cell Lines is underscored by their application in basic research aimed at understanding gene function and its implications in health and disease. They can serve as valuable tools in drug screening, biomarker discovery, and identifying therapeutic targets, thereby contributing significantly to translational medicine.

One of the primary advantages of these cell lines is their specificity and reliability compared to traditional knockout methods, which may exhibit variable results due to off-target effects. Our CTBP2 Gene Knockout Cell Lines are validated for consistency and efficacy, ensuring reproducible data for researchers across various fields, including molecular biology, genetics, and oncology.

By leveraging the innovation behind our CTBP2 Gene Knockout Cell Lines, researchers and clinicians can propel their studies forward with confidence, unraveling the complexities of associated diseases. Our company specializes in providing high-quality genetic models backed by rigorous scientific validation and support, establishing us as a trusted partner in advancing biological research.

Please note that all services are for research use only. Not intended for any clinical use.

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