Gene: CSTB
Official Full Name: cystatin Bprovided by HGNC
Gene Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38374 | CSTB Knockout cell line (HeLa) | Human | CSTB | 1:3~1:6 | Negative | Online Inquiry |
KO38375 | CSTB Knockout cell line (HCT 116) | Human | CSTB | 1:2~1:4 | Negative | Online Inquiry |
KO38376 | CSTB Knockout cell line (HEK293) | Human | CSTB | 1:3~1:6 | Negative | Online Inquiry |
KO38377 | CSTB Knockout cell line (A549) | Human | CSTB | 1:3~1:4 | Negative | Online Inquiry |
CSTB Gene Knockout Cell Lines represent a cutting-edge biotechnological tool designed for the investigation and manipulation of gene function within mammalian cells. These cell lines are specifically engineered to disrupt the function of the cystatin B (CSTB) gene, which encodes a cysteine protease inhibitor implicated in various neurological disorders, including Uncombable Hair Syndrome. By providing researchers with a robust platform to study the effects of CSTB deficiency, these cell lines enable detailed analyses of molecular pathways, cellular processes, and disease mechanisms.
The key function of CSTB Gene Knockout Cell Lines lies in their ability to facilitate gene editing techniques, such as CRISPR-Cas9, leading to precise deletions of the CSTB gene. This knockout approach elucidates the gene's role in cellular signaling, pathways of apoptosis, and responses to stress. The resulting changes in cell behavior, protein expression, and signaling cascades can be evaluated using a variety of methods, ranging from functional assays to advanced imaging techniques, allowing for comprehensive studies pertinent to neurobiology and therapeutic development.
The scientific importance of these cell lines is underscored by their application in both research and clinical contexts. Researchers can harness these models to uncover insights into disease mechanisms, aiding the discovery of novel therapeutic targets for conditions linked to CSTB dysfunction. Furthermore, their use in preclinical studies allows for the rigorous testing of drug candidates and treatment strategies, ultimately translating basic research into clinical practice.
Compared to alternative gene knockout tools, CSTB Gene Knockout Cell Lines offer enhanced specificity, reproducibility, and cell viability, which are critical for ensuring reliable experimental outcomes. The unique selling point of our product lies in its ease of use and versatility across various platforms, making it an ideal choice for laboratories with diverse research needs.
Researchers, clinicians, and biopharmaceutical companies will find exceptional value in CSTB Gene Knockout Cell Lines, as they offer unprecedented insights into gene function and disease pathology. Our commitment to high-quality biological products is reflected in each cell line we provide, supported by years of expertise in genetic engineering and cell biology. Choose CSTB Gene Knockout Cell Lines for your research needs and elevate your understanding of complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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