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CSTA Knockout Cell Lines

Gene: CSTA

Official Full Name: cystatin Aprovided by HGNC

Gene Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins, and kininogens. This gene encodes a stefin that functions as a cysteine protease inhibitor, forming tight complexes with papain and the cathepsins B, H, and L. The protein is one of the precursor proteins of cornified cell envelope in keratinocytes and plays a role in epidermal development and maintenance. Stefins have been proposed as prognostic and diagnostic tools for cancer. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38378 CSTA Knockout cell line (HCT 116) Human CSTA 1:2~1:4 Negative Online Inquiry
KO38379 CSTA Knockout cell line (A549) Human CSTA 1:3~1:4 Negative Online Inquiry

Background

CSTA Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to investigate the functional roles of the Cystatin A (CSTA) gene, known for its involvement in various homeostatic and pathological processes. These cell lines are created through the precise CRISPR-Cas9 gene-editing technology, which allows for the targeted disruption of the CSTA gene. By generating knockout variants, researchers can study the loss-of-function effects on cellular behavior, signaling pathways, and interactions, thereby elucidating the gene's role in health and disease.

The primary function of CSTA Gene Knockout Cell Lines lies in their ability to mimic disease conditions by providing a platform to observe direct consequences of CSTA gene loss. This mechanism enables comprehensive studies into cancer biology, autoimmune responses, and neurodegenerative diseases, among other areas. The knockout models facilitate investigations into altered cellular dynamics, such as changes in apoptosis, proliferation, and cellular stress responses, resulting in a more profound understanding of disease mechanisms.

From a scientific perspective, these cell lines are invaluable in both research and clinical applications. They allow for the validation of therapeutic targets and biomarker discovery, significantly advancing drug development processes. Moreover, their utility extends beyond basic research; CSTA knockouts can serve as screening tools in pharmacological studies, where the effects of novel compounds can be assessed more accurately.

What sets CSTA Gene Knockout Cell Lines apart from alternative products is their high specificity and efficiency, proven stability, and user-friendly protocols optimized for rapid validation and functional assays. Unlike generalized knockout systems, these cell lines target CSTA expression with high precision, enabling unparalleled insights into its biological functions without the noise of off-target effects.

These advanced biological tools are particularly valuable for researchers and clinicians striving to unravel complex molecular mechanisms and develop targeted therapies. By integrating CSTA Gene Knockout Cell Lines into research workflows, professionals can accelerate their discoveries and contribute to transformative advancements in biomedical science.

Our company specializes in high-quality, innovative biological products tailored for research communities, and we are dedicated to providing the resources that enable breakthroughs in understanding gene function and its implications in human health.

Please note that all services are for research use only. Not intended for any clinical use.

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