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CST6 Knockout Cell Lines

Gene: CST6

Official Full Name: cystatin E/Mprovided by HGNC

Gene Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. This gene encodes a cystatin from the type 2 family, which is down-regulated in metastatic breast tumor cells as compared to primary tumor cells. Loss of expression is likely associated with the progression of a primary tumor to a metastatic phenotype. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38380 CST6 Knockout cell line (HCT 116) Human CST6 1:2~1:4 Negative Online Inquiry

Background

CST6 Gene Knockout Cell Lines are engineered cellular models specifically designed for in-depth research of the cystatin M/E (CST6) gene, which plays a pivotal role in cellular protease inhibition and modulates critical processes such as tumor progression and immune response. By utilizing CRISPR/Cas9 gene editing technology, these cell lines exhibit a complete knockout of the CST6 gene, allowing investigators to explore the resultant phenotypic changes and underlying molecular mechanisms in a controlled environment.

The primary function of CST6 Gene Knockout Cell Lines is to facilitate the analysis of the biological consequences of CST6 deficiency. Researchers can examine the differences in protease activity, cellular proliferation, apoptosis, and the tumor microenvironment in comparison to wild-type counterparts. This gene knockout model is essential for elucidating CST6's role in cancer biology and other pathological conditions, thereby fostering a deeper understanding of its potential as a therapeutic target.

In both research and clinical settings, these knockout cell lines become invaluable tools for drug discovery and validation, providing insights into novel treatment strategies that inhibit tumor growth or enhance immune responses. Since CST6 is implicated in various forms of malignancies, including breast cancer, these models are integral for studies aimed at developing CST6-targeted therapies.

What distinguishes CST6 Gene Knockout Cell Lines from alternative models is their specificity and precise genetic alterations, which ensure reproducibility and accuracy in experimental outcomes. The ability to study the CST6 pathway in isolation helps overcome the complexities inherent in whole-organism studies, delivering clear and actionable data for further exploration.

Our commitment to advancing scientific inquiry is reflected in the high-quality production and validation of our CST6 Gene Knockout Cell Lines. We leverage our extensive expertise in molecular biology and genetics to provide researchers and clinicians with tools that empower discovery and innovation in the life sciences. Through these cell lines, we are dedicated to supporting breakthroughs that can ultimately lead to improved therapeutic avenues in oncology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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