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CSPG4 Knockout Cell Lines

Gene: CSPG4

Official Full Name: chondroitin sulfate proteoglycan 4provided by HGNC

Gene Summary: A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07273 CSPG4 Knockout cell line (HeLa) Human CSPG4 1:3~1:6 Negative Online Inquiry
KO07274 CSPG4 Knockout cell line (HCT 116) Human CSPG4 1:2~1:4 Negative Online Inquiry

Background

CSPG4 Gene Knockout Cell Lines are genetically engineered cell lines that have had the CSPG4 gene, known for its role in various cellular processes and associated with numerous pathologies, including melanoma and glioma, disrupted. By utilizing CRISPR-Cas9 technology, these cell lines enable researchers to investigate the biological functions of CSPG4, assess its contributions to tumorigenesis, and explore potential therapeutic interventions.

The key function of CSPG4 gene knockout is to provide an in vitro model for studying the absence of CSPG4-specific activities, thereby elucidating its role in cell adhesion, migration, and signaling pathways. Researchers can exploit these knockout lines to better understand the cellular mechanisms contributing to cancer progression and to identify novel biomarkers for disease diagnosis and prognosis. This approach allows for the analysis of gene function in a controlled environment, offering insights into the gene's influence on the tumor microenvironment and immune response.

The scientific importance of CSPG4 Gene Knockout Cell Lines lies in their applicability to both basic research and clinical settings. In research, these cell lines facilitate the identification of therapeutic targets and the development of CSPG4-related treatments. In clinical contexts, understanding CSPG4 interactions can lead to enhanced cancer treatment strategies and improve patient outcomes.

What sets CSPG4 Gene Knockout Cell Lines apart from alternatives is their high specificity and reproducibility in studies. They are rigorously validated to ensure that the phenotype observed is a direct consequence of the CSPG4 knockout, providing researchers with confidence in their experimental results. Additionally, the availability of these lines in various genetic backgrounds enhances their utility across different research applications.

Researchers, clinicians, and companies focused on oncology can significantly benefit from CSPG4 Gene Knockout Cell Lines as they represent a powerful tool for advancing cancer research and developing targeted therapies. By leveraging these state-of-the-art models, users can accelerate their discoveries and enhance the efficacy of their investigations.

Our company specializes in providing high-quality biological products designed to empower scientific discovery. With a commitment to excellence and innovation, we ensure that our offerings, including CSPG4 Gene Knockout Cell Lines, meet the highest research standards, supporting our customers in their pursuit of groundbreaking research and clinical advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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