Home / CSNK1G1 Knockout Cell Lines

CSNK1G1 Knockout Cell Lines

Gene: CSNK1G1

Official Full Name: casein kinase 1 gamma 1provided by HGNC

Gene Summary: This gene encodes a member of the casein kinase I gene family. This family is comprised of serine/threonine kinases that phosphorylate acidic proteins such as caseins. The encoded kinase plays a role in cell cycle checkpoint arrest in response to stalled replication forks by phosphorylating Claspin. A mutation in this gene may be associated with non-syndromic early-onset epilepsy (NSEOE). [provided by RefSeq, Jul 2016]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO10092 CSNK1G1 Knockout cell line (HeLa) Human CSNK1G1 1:3~1:6 Negative Online Inquiry
KO10093 CSNK1G1 Knockout cell line (HCT 116) Human CSNK1G1 1:2~1:4 Negative Online Inquiry
KO10094 CSNK1G1 Knockout cell line (HEK293) Human CSNK1G1 1:3~1:6 Negative Online Inquiry
KO10095 CSNK1G1 Knockout cell line (A549) Human CSNK1G1 1:3~1:4 Negative Online Inquiry

Background

CSNK1G1 Gene Knockout Cell Lines represent a groundbreaking tool in genetic research, designed specifically for the functional analysis of the casein kinase 1 gamma 1 (CSNK1G1) gene. These cell lines are derived from human or murine cells where the CSNK1G1 gene has been systematically disrupted, allowing researchers to study the consequences of gene loss on cellular behavior, signaling pathways, and overall physiology.

The key function of these knockout cell lines is to facilitate the in-depth investigation of CSNK1G1's role in various biological processes, including cellular proliferation, differentiation, and apoptosis. By utilizing CRISPR-Cas9 technology or similar gene-editing techniques, each cell line maintains a consistent loss-of-function mutation, thus enabling reproducibility across experiments. Researchers can employ these models to elucidate the downstream effects of CSNK1G1 dysregulation, which has important implications in cancer biology, neurodegenerative diseases, and metabolic disorders.

The scientific importance of CSNK1G1 Gene Knockout Cell Lines lies in their ability to provide insights into the molecular mechanisms underpinning complex diseases and physiological conditions. In clinical settings, these models can advance drug discovery by offering a refined platform for testing therapeutic interventions targeting CSNK1G1-related pathways, which could lead to significant breakthroughs in personalized medicine.

Compared to traditional gene silencing methods, such as RNA interference, CSNK1G1 knockout cell lines provide a permanent, stable model that eliminates off-target effects and assures that phenotypic changes directly stem from the gene knockout. Their specificity and robustness make them a preferable choice for researchers seeking reliable data.

The value of CSNK1G1 Gene Knockout Cell Lines extends beyond basic research; they empower scientists and clinicians alike to uncover vital biological networks critical for health and disease management. With our commitment to quality and innovation, our company harnesses cutting-edge genetic engineering techniques to provide tools that inspire and drive the future of biomedical research.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.