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CSK Knockout Cell Lines

Gene: CSK

Official Full Name: C-terminal Src kinaseprovided by HGNC

Gene Summary: The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38394 CSK Knockout cell line (HeLa) Human CSK 1:3~1:6 Negative Online Inquiry
KO38395 CSK Knockout cell line (HCT 116) Human CSK 1:2~1:4 Negative Online Inquiry
KO38396 CSK Knockout cell line (HEK293) Human CSK 1:3~1:6 Negative Online Inquiry
KO38397 CSK Knockout cell line (A549) Human CSK 1:3~1:4 Negative Online Inquiry

Background

CSK Gene Knockout Cell Lines are specialized experimental tools developed for gene manipulation studies in cellular biology. These engineered cell lines have been created through precise CRISPR-Cas9 technology to achieve targeted gene disruption, allowing researchers to investigate the effects of specific gene deletions on cellular function and behavior. Each cell line is meticulously characterized to ensure the reliability and reproducibility of experimental results across a variety of research applications.

The primary function of CSK Gene Knockout Cell Lines is to serve as a platform for the study of gene function, interactions, and pathways that contribute to various biological processes, disease mechanisms, and therapeutic targets. By providing a straightforward approach to gene knockout, these cell lines facilitate functional genomic studies, enabling the elucidation of gene roles and the development of potential novel treatment strategies in a range of fields such as oncology, neurobiology, and developmental biology.

The scientific importance of these cell lines lies in their application in both research and clinical settings, where they can be utilized for drug discovery, disease modeling, and biomarker identification. Researchers can leverage these tools to identify gene functions that may be critical in disease progression or therapeutic resistance, thereby advancing our understanding of complex biological systems.

Compared to alternative gene knockout techniques, such as traditional homologous recombination, CSK Gene Knockout Cell Lines present a quicker and more efficient method for generating knockout models with fewer off-target effects. Additionally, the ease of use and the robustness of these cell lines make them an attractive choice for laboratories aiming to minimize experimental variability and streamline workflow.

For researchers and clinicians alike, the value of CSK Gene Knockout Cell Lines lies in their ability to provide clear insights into gene functionality and their potential roles in disease states. This product not only enhances experimental accuracy but also accelerates the pace of scientific discovery.

Our company is dedicated to advancing biological innovation and quality, offering an extensive portfolio of biological products designed to support groundbreaking research endeavors. Our expertise in gene editing technologies ensures that our customers have access to the most advanced tools available for their scientific inquiries.

Please note that all services are for research use only. Not intended for any clinical use.

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