Gene: CRYBB3
Official Full Name: crystallin beta B3provided by HGNC
Gene Summary: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of different sizes and are able to self-associate to form dimers or to form heterodimers with other beta-crystallins. This gene, a beta basic group member, is part of a gene cluster with beta-A4, beta-B1, and beta-B2. Mutations in this gene result in cataract congenital nuclear autosomal recessive type 2. [provided by RefSeq, Feb 2013]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38413 | CRYBB3 Knockout cell line (HEK293) | Human | CRYBB3 | 1:3~1:6 | Negative | Online Inquiry |
CRYBB3 Gene Knockout Cell Lines are genetically engineered cell lines in which the CRYBB3 gene has been selectively disrupted or inactivated. This process is achieved using state-of-the-art CRISPR-Cas9 gene-editing technology, allowing for precise modifications that enable researchers to study the functional role of the CRYBB3 protein in various biological processes. The absence of CRYBB3 allows scientists to investigate its implications in conditions such as cataracts and other ocular disorders, elucidating the underlying mechanisms at play.
The primary function of these knockout cell lines hinges on their ability to create a controlled environment that permits the examination of CRYBB3's involvement in cellular responses, differentiation, and protein interactions. The mechanism of action allows researchers to assess phenotypic changes, metabolic pathways, and potential compensatory mechanisms that arise from the gene disruption, providing valuable insights into cellular physiology and pathology.
Scientifically, CRYBB3 Gene Knockout Cell Lines hold significant relevance in both research and clinical applications. They serve as pivotal tools in drug discovery and development, enabling high-throughput screening for therapeutic agents targeting abnormalities associated with the CRYBB3 protein. Additionally, these cell lines facilitate the study of gene functions in the context of ocular diseases, contributing to the development of innovative treatments and interventions.
Unlike other knockout models, the specificity and precision of our CRYBB3 Gene Knockout Cell Lines ensure minimal off-target effects, enhancing the reliability of experimental results. This precision allows researchers to draw more accurate conclusions regarding the gene's functional role, offering a competitive advantage in the field of genetic research.
Researchers and clinicians alike will find value in utilizing CRYBB3 Gene Knockout Cell Lines for their studies, as they offer a unique platform for exploration and therapeutic advancement. By choosing our product, users can expect reliable, reproducible results while contributing to the broader understanding of genetic contributions to human health.
At [Your Company Name], we are committed to advancing scientific research through high-quality biological products. With extensive expertise in genetic engineering and a focus on innovative solutions, we provide tools that empower researchers to push the boundaries of knowledge in genetic and cellular biology.
Please note that all services are for research use only. Not intended for any clinical use.
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