Gene: CRY2
Official Full Name: cryptochrome circadian regulator 2provided by HGNC
Gene Summary: This gene encodes a flavin adenine dinucleotide-binding protein that is a key component of the circadian core oscillator complex, which regulates the circadian clock. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene have been associated with altered sleep patterns. The encoded protein is widely conserved across plants and animals. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38418 | CRY2 Knockout cell line (HeLa) | Human | CRY2 | 1:3~1:6 | Negative | Online Inquiry |
KO38419 | CRY2 Knockout cell line (HCT 116) | Human | CRY2 | 1:2~1:4 | Negative | Online Inquiry |
KO38420 | CRY2 Knockout cell line (HEK293) | Human | CRY2 | 1:3~1:6 | Negative | Online Inquiry |
KO38421 | CRY2 Knockout cell line (A549) | Human | CRY2 | 1:3~1:4 | Negative | Online Inquiry |
CRY2 Gene Knockout Cell Lines represent a pioneering biomedical tool designed for the study of circadian rhythms and photoreception. These engineered cell lines have been developed using CRISPR-Cas9 technology to knock out the CRY2 gene, which encodes a crucial component of the circadian clock mechanism in mammals. The absence of CRY2 offers researchers the unique ability to delve into the intricate roles that circadian genes play in cellular processes, metabolism, and even disease states.
The functionality of CRY2 knockout cell lines lies in their capacity to enhance the understanding of circadian biology by facilitating the investigation of downstream signaling pathways activated by light and circadian cues. This genetic alteration provides a valuable model for assessing how disruptions in circadian rhythms can lead to conditions such as sleep disorders, metabolic syndromes, and certain cancers. Researchers can utilize these cell lines for various applications, including drug screening, gene expression studies, and the exploration of potential therapeutic targets.
One of the significant advantages of our CRY2 Gene Knockout Cell Lines over alternative models is the precision and efficiency achieved through CRISPR technology, which allows for a clean and specific gene excision. Additionally, these cell lines are rigorously validated to ensure consistent performance in experimental settings, providing reliable data that can accelerate research outcomes.
By integrating these unique cell lines into their workflows, researchers and clinicians can unlock new avenues in their studies and trials, driving forward the understanding of biological processes with potential therapeutic implications. Our company is committed to advancing research initiatives in circadian biology, and with a robust background in genetic engineering and cell line development, we dedicate ourselves to providing researchers the tools they need to pioneer significant discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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