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CRTC1 Knockout Cell Lines

Gene: CRTC1

Official Full Name: CREB regulated transcription coactivator 1provided by HGNC

Gene Summary: Enables cAMP response element binding protein binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol; nuclear body; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO29369 CRTC1 Knockout cell line (HeLa) Human CRTC1 1:3~1:6 Negative Online Inquiry
KO29370 CRTC1 Knockout cell line (HCT 116) Human CRTC1 1:2~1:4 Negative Online Inquiry
KO29371 CRTC1 Knockout cell line (HEK293) Human CRTC1 1:3~1:6 Negative Online Inquiry
KO29372 CRTC1 Knockout cell line (A549) Human CRTC1 1:3~1:4 Negative Online Inquiry

Background

CRTC1 Gene Knockout Cell Lines are genetically modified cell lines designed to precisely eliminate the expression of the CRTC1 gene, which encodes a critical protein involved in the regulation of various cellular processes, including metabolic pathways and stress responses. The development of these knockout models allows researchers to investigate the functional role of CRTC1 in different biological contexts, particularly in relation to metabolic disorders, cancer, and neurodegenerative diseases.

These cell lines work through the application of CRISPR/Cas9 gene-editing technology, whereby targeted double-strand breaks in the DNA lead to the disruption of the CRTC1 gene. This robust mechanism of action enables researchers to create a stable knockout, facilitating studies on the downstream effects of CRTC1 loss on cellular phenotype, signal transduction pathways, and gene expression profiles. Given the pivotal role of CRTC1 in regulating energy homeostasis, its knockout can provide valuable insights into complex diseases like obesity and diabetes.

The scientific importance of CRTC1 Gene Knockout Cell Lines extends into diverse research domains, as they serve as vital tools in elucidating the molecular mechanisms underlying various pathologies. Additionally, these cell lines can aid drug discovery efforts by allowing for the evaluation of therapeutic interventions that target CRTC1-related pathways, thereby accelerating the development of novel treatments.

What sets CRTC1 Gene Knockout Cell Lines apart from alternative models is their genetic precision, consistency, and reproducibility, which ensure the reliability of experimental results. Unlike other knockout strategies that may inadvertently affect neighboring genes, our cell lines provide a clean genetic background tailored to the scientific community’s needs.

For researchers and clinicians, the value of utilizing CRTC1 Gene Knockout Cell Lines lies in their ability to advance knowledge in molecular biology and therapeutic development while fostering innovations in personalized medicine. By understanding the nuances of gene function and regulation, these cell lines contribute to a deeper comprehension of disease mechanisms and treatment possibilities.

Our company is dedicated to providing high-quality biological products backed by advanced genetic engineering expertise. With a commitment to innovation and scientific integrity, we aim to support the research community in their quest for breakthroughs in health and disease understanding.

Please note that all services are for research use only. Not intended for any clinical use.

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