Gene: CREG1
Official Full Name: cellular repressor of E1A stimulated genes 1provided by HGNC
Gene Summary: The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33840 | CREG1 Knockout cell line (HeLa) | Human | CREG1 | 1:3~1:6 | Negative | Online Inquiry |
KO33841 | CREG1 Knockout cell line (HCT 116) | Human | CREG1 | 1:2~1:4 | Negative | Online Inquiry |
KO33842 | CREG1 Knockout cell line (HEK293) | Human | CREG1 | 1:3~1:6 | Negative | Online Inquiry |
KO33843 | CREG1 Knockout cell line (A549) | Human | CREG1 | 1:3~1:4 | Negative | Online Inquiry |
CREG1 Gene Knockout Cell Lines are specialized cellular models developed to facilitate the functional analysis of the CREG1 gene, which is implicated in various biological processes, including cellular growth, differentiation, and tissue repair. By employing CRISPR-Cas9 genome editing technology, these cell lines have been engineered to completely disable the CREG1 gene, allowing researchers to study the consequences of its absence on cellular behavior and signaling pathways.
The primary mechanism of the CREG1 Gene Knockout Cell Lines involves the precise alteration of the genomic DNA at the CREG1 locus, leading to a loss of function and subsequent phenotypic changes in the cells. This tool enables scientists to dissect the role of CREG1 in vital cellular processes, thereby illuminating its contributions to health and disease, such as cancer and regenerative medicine.
The scientific significance of these knockout cell lines cannot be overstated, as they provide an invaluable resource in both academic and pharmaceutical research settings. They are instrumental for elucidating gene function and assessing the therapeutic potentials of targeting the CREG1 pathway, making them particularly relevant for drug discovery and development efforts.
Compared to alternative models like wild-type cell lines or less specific knockdown techniques, the CREG1 Gene Knockout Cell Lines offer several advantages, including complete gene inactivation, consistency in experimental setups, and the ability to generate more relevant biological insights. These characteristics enhance reproducibility in research, thereby empowering scientists to obtain more reliable data.
Given the ongoing challenge of understanding gene functions in complex biological systems, the CREG1 Gene Knockout Cell Lines are essential for researchers and clinicians committed to advancing knowledge in genetics, cell biology, and disease mechanisms. Our company draws on extensive expertise in molecular biology and genetic engineering to deliver top-quality products that promote innovation in life sciences research.
Please note that all services are for research use only. Not intended for any clinical use.
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