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CR2 Knockout Cell Lines

Gene: CR2

Official Full Name: complement C3d receptor 2provided by HGNC

Gene Summary: This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01947 CR2 Knockout cell line (HCT 116) Human CR2 1:2~1:4 Negative Online Inquiry
KO01948 CR2 Knockout cell line (HEK293) Human CR2 1:3~1:6 Negative Online Inquiry

Background

CR2 Gene Knockout Cell Lines are engineered cellular models that have undergone precise genetic modification to disable the CR2 gene, a critical component in the immune response. This knockout technology employs advanced CRISPR-Cas9 gene editing techniques to generate cell lines that facilitate the study of immune system dynamics, particularly in relation to B cell receptor signaling and complement activation.

The primary function of these cell lines lies in their ability to elucidate the role of CR2 in various biological processes, including immune response modulation, cellular communication, and pathogenic interactions. By observing the effects of CR2 knockout in vitro, researchers can dissect the mechanisms of immune dysfunction, paving the way for insights that could lead to novel therapeutic approaches for autoimmune diseases, immunodeficiencies, and infectious diseases.

In research and clinical settings, CR2 Gene Knockout Cell Lines are invaluable for exploring the pathways that govern immune behavior and disease etiology. They can serve as tools for drug discovery, biomarker validation, and therapeutic development, providing a robust platform for the testing of immunomodulatory compounds. The specificity of these cell lines allows for the differentiation of CR2-related pathways from other immune processes, thus enriching the quality of experimental data.

What sets our CR2 Gene Knockout Cell Lines apart from alternative models is their high efficiency and reliability, featuring validated knockout efficiency rates above 90%. Additionally, these cell lines are fully characterized and available in multiple backgrounds, ensuring flexibility for various experimental requirements. Our commitment to rigorous quality control ensures reproducibility, a critical factor for researchers striving for high standards in their investigations.

The value of CR2 Gene Knockout Cell Lines to researchers and clinicians cannot be understated, as they enable deeper understanding of immune mechanisms and support the development of targeted interventions. We pride ourselves on our expertise in genetic engineering and cellular biology, providing superior biological products designed to advance scientific research and innovation.

Please note that all services are for research use only. Not intended for any clinical use.

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