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COX20 Knockout Cell Lines

Gene: COX20

Official Full Name: cytochrome c oxidase assembly factor COX20provided by HGNC

Gene Summary: This gene encodes a protein that plays a role in the assembly of cytochrome C oxidase, an important component of the respiratory pathway. It contains two transmembrane helices and localizes to the mitochondrial membrane. Mutations in this gene can cause mitochondrial complex IV deficiency, which results in ataxia and muscle hypotonia. There are multiple pseudogenes for this gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30542 COX20 Knockout cell line (HeLa) Human COX20 1:3~1:6 Negative Online Inquiry
KO30543 COX20 Knockout cell line (HCT 116) Human COX20 1:2~1:4 Negative Online Inquiry
KO30544 COX20 Knockout cell line (HEK293) Human COX20 1:3~1:6 Negative Online Inquiry
KO30545 COX20 Knockout cell line (A549) Human COX20 1:3~1:4 Negative Online Inquiry

Background

COX20 Gene Knockout Cell Lines are specialized cell culture models characterized by the disruption of the COX20 gene, which is implicated in mitochondrial function and energy metabolism. These genetically engineered cell lines serve as invaluable tools for the exploration of cellular respiration processes and mitochondrial dysfunction, which are critical in studies of aging, neurodegenerative diseases, and metabolic disorders. These cell lines enable researchers to dissect the role of COX20 in mitochondrial biogenesis and the oxidative phosphorylation pathway, allowing for the identification of therapeutic targets.

The key function of COX20 involves its role in the assembly and stability of cytochrome c oxidase, a vital component of the mitochondrial respiratory chain. By utilizing COX20 knockout cell lines, researchers can observe the consequences of gene deletion on mitochondrial integrity and functionality, effectively mimicking pathological conditions where COX20 function is impaired. This mechanism allows for a deeper understanding of the molecular underpinnings of diseases associated with mitochondrial dysfunction.

The scientific importance of COX20 Gene Knockout Cell Lines extends to both fundamental research and clinical applications. They are instrumental in the development of drugs aimed at correcting mitochondrial defects, as well as in gene therapy strategies targeting mitochondrial diseases. Furthermore, their application in high-throughput screening for compounds that can restore normal mitochondrial function represents a significant advancement in drug discovery.

One distinct advantage of our COX20 Gene Knockout Cell Lines is the purity and reliability of the cellular models. Each line is validated through next-generation sequencing and functional assays, ensuring consistent phenotype expression that researchers can trust. This contrasts with alternative models that may exhibit variability or incomplete knockout characteristics.

For researchers and clinicians, the value of utilizing COX20 Gene Knockout Cell Lines lies in their capacity to empower the investigation of mitochondrial biology and the development of innovative therapeutic approaches. These models not only enhance the understanding of mitochondrial diseases but also facilitate breakthroughs in personalized medicine by providing tailored experimental conditions.

Our company prides itself on its commitment to excellence and innovation within the realm of biological products. With expertise in advanced genetic engineering techniques and a robust track record in cellular model development, we are dedicated to supporting the scientific community in achieving novel discoveries that can translate into impactful clinical advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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