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COX18 Knockout Cell Lines

Gene: COX18

Official Full Name: cytochrome c oxidase assembly factor COX18provided by HGNC

Gene Summary: This gene encodes a cytochrome c oxidase assembly protein. The encoded protein is essential for integral membrane protein insertion into the mitochondrial inner membrane. It is also required for cytochrome c oxidase assembly and activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18581 COX18 Knockout cell line (HeLa) Human COX18 1:3~1:6 Negative Online Inquiry
KO18582 COX18 Knockout cell line (HCT 116) Human COX18 1:2~1:4 Negative Online Inquiry
KO18583 COX18 Knockout cell line (HEK293) Human COX18 1:3~1:6 Negative Online Inquiry
KO18584 COX18 Knockout cell line (A549) Human COX18 1:3~1:4 Negative Online Inquiry

Background

COX18 Gene Knockout Cell Lines are specifically engineered cellular models designed to facilitate the study of the COX18 gene, which is integral to mitochondrial biogenesis and the proper assembly of cytochrome c oxidase, a key component of the electron transport chain. These cell lines have been meticulously curated through gene editing technologies, such as CRISPR-Cas9, which allow for precise knockout of the COX18 gene, enabling researchers to observe the subsequent physiological changes and to elucidate the gene's role in cellular metabolism.

The primary mechanism of COX18 knockout cell lines involves the disruption of the gene responsible for cytochrome c oxidase assembly, leading to impaired oxidative phosphorylation and altered energy metabolism. This model is invaluable for exploring the downstream effects of COX18 deficiency, including cellular stress responses, apoptosis, and changes in mitochondrial dynamics. Scientists can utilize these knockout lines to investigate pathologies associated with mitochondrial dysfunction, such as neurodegenerative diseases, cancer, and metabolic disorders.

The scientific importance of COX18 Gene Knockout Cell Lines extends into both research and clinical applications. They serve as critical tools for drug discovery, potential therapeutic target validation, and elucidating metabolic pathways influenced by mitochondrial health. Researchers looking to understand the physiological implications of COX18 loss will find these cell lines indispensable.

What sets our COX18 Gene Knockout Cell Lines apart from alternative models is their high specificity and reproducibility. Each cell line undergoes rigorous validation for genetic integrity and functional consistency, ensuring that researchers get reliable and reproducible results. Our lines provide a robust platform for experimentation with clear and interpretable outcomes, minimizing the noise often associated with less precise models.

Investing in COX18 Gene Knockout Cell Lines will empower researchers and clinicians with the tools they need to push the boundaries of mitochondrial biology. With a commitment to quality and innovation, our company is dedicated to providing top-tier biological products that advance research and contribute to groundbreaking scientific discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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