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CORO2B Knockout Cell Lines

Gene: CORO2B

Official Full Name: coronin 2Bprovided by HGNC

Gene Summary: Enables talin binding activity and vinculin binding activity. Acts upstream of or within several processes, including negative regulation of cell-substrate adhesion; regulation of actin cytoskeleton organization; and regulation of establishment of protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO31923 CORO2B Knockout cell line (HeLa) Human CORO2B 1:3~1:6 Negative Online Inquiry
KO31924 CORO2B Knockout cell line (HCT 116) Human CORO2B 1:2~1:4 Negative Online Inquiry
KO31925 CORO2B Knockout cell line (HEK293) Human CORO2B 1:3~1:6 Negative Online Inquiry
KO31926 CORO2B Knockout cell line (A549) Human CORO2B 1:3~1:4 Negative Online Inquiry

Background

CORO2B Gene Knockout Cell Lines are a cutting-edge biological tool designed to facilitate the study of the CORO2B gene, known for its critical role in cellular processes such as cytoskeleton organization and intracellular transport. These cell lines have been engineered using CRISPR/Cas9 technology to create a specific knockout of the CORO2B gene, enabling researchers to investigate the functional implications of gene loss in various cellular contexts.

The primary mechanism of action involves the targeted disruption of the CORO2B gene, leading to a loss of protein expression. This knockout model allows for in-depth studies on the gene's involvement in cellular dynamics, signaling pathways, and its contribution to disease states, particularly in conditions like cancer and neurodegenerative disorders. By utilizing CORO2B Gene Knockout Cell Lines, researchers can develop insights into gene function and interaction that are crucial for advancing therapeutic strategies.

The scientific importance of these cell lines lies in their capacity to enhance our understanding of gene function and regulation in a controlled environment. In clinical research settings, these tools can assist in drug discovery and the development of gene therapies by identifying potential targets for intervention.

Compared to alternative models, such as traditional knockout methodologies or RNA interference (RNAi), the CORO2B Gene Knockout Cell Lines provide higher specificity, efficiency, and reproducibility. Furthermore, this product streamlines the investigation of gene function by eliminating the variability often associated with chemical inhibition or transient gene silencing techniques.

For researchers, the ability to create precise and validated models significantly accelerates the pace of discovery, facilitating reproducible results that can be readily applied to therapeutic development. Clinicians will find these cell lines invaluable for translational research, enabling a clearer pathway from bench to bedside.

Our company specializes in providing top-tier biological products and technologies that empower researchers and clinicians alike. With the CORO2B Gene Knockout Cell Lines, we are committed to advancing scientific knowledge and supporting groundbreaking research that has the potential to transform healthcare outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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