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COQ10B Knockout Cell Lines

Gene: COQ10B

Official Full Name: coenzyme Q10Bprovided by HGNC

Gene Summary: Predicted to enable ubiquinone binding activity. Predicted to be involved in cellular respiration. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO26116 COQ10B Knockout cell line (HeLa) Human COQ10B 1:3~1:6 Negative Online Inquiry
KO26117 COQ10B Knockout cell line (HCT 116) Human COQ10B 1:2~1:4 Negative Online Inquiry
KO26118 COQ10B Knockout cell line (HEK293) Human COQ10B 1:3~1:6 Negative Online Inquiry
KO26119 COQ10B Knockout cell line (A549) Human COQ10B 1:3~1:4 Negative Online Inquiry

Background

COQ10B Gene Knockout Cell Lines are genetically engineered cell lines specifically designed to lack the functional COQ10B gene, which is essential in the biosynthetic pathway of coenzyme Q10 (CoQ10). CoQ10 is a critical cofactor involved in mitochondrial energy production and oxidative phosphorylation. Its absence in these cell lines allows researchers to investigate the role of COQ10B in cellular metabolism, energy production, and associated metabolic disorders without the interference of the wild-type gene's activity.

The key functions of COQ10B Gene Knockout Cell Lines reside in their ability to serve as a powerful model for studying the effects of CoQ10 deficiency on cellular processes, including apoptosis, oxidative stress response, and mitochondrial dysfunction. By elucidating the mechanisms underlying these pathways, researchers can gain insights into various conditions such as cardiovascular diseases, neurodegenerative disorders, and myopathies where CoQ10 plays a crucial therapeutic role.

In clinical settings, the application of these knockout cell lines extends to drug development and testing, allowing for the assessment of therapeutic compounds aimed at alleviating symptoms associated with CoQ10 deficiency. Compared to traditional cellular models, our COQ10B Gene Knockout Cell Lines provide a more accurate representation of the disease state, thereby enhancing the translational potential of research findings.

One of the notable advantages of our product over competitors is the precision and reliability in genome editing that ensures complete absence of COQ10B activity, thus minimizing background effects. Our offering comes supported by comprehensive technical documentation and a team of experts ready to assist users in experimental design and data interpretation, ensuring that researchers can maximize the utility of these cell lines.

The value of COQ10B Gene Knockout Cell Lines lies not only in their scientific applications but also in their capacity to facilitate advancements in understanding mitochondrial biology and related pathologies. At [Your Company], we pride ourselves on delivering cutting-edge biological tools, backed by extensive research and development expertise, to empower researchers and clinicians in their quest for discovery and innovation in health science.

Please note that all services are for research use only. Not intended for any clinical use.

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