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COMMD4 Knockout Cell Lines

Gene: COMMD4

Official Full Name: COMM domain containing 4provided by HGNC

Gene Summary: Predicted to be involved in signal transduction. Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18605 COMMD4 Knockout cell line (HeLa) Human COMMD4 1:3~1:6 Negative Online Inquiry
KO18606 COMMD4 Knockout cell line (HCT 116) Human COMMD4 1:2~1:4 Negative Online Inquiry
KO18607 COMMD4 Knockout cell line (HEK293) Human COMMD4 1:3~1:6 Negative Online Inquiry
KO18608 COMMD4 Knockout cell line (A549) Human COMMD4 1:3~1:4 Negative Online Inquiry

Background

COMMD4 Gene Knockout Cell Lines are specifically engineered cellular models that have had the COMMD4 gene effectively disrupted or "knocked out." This gene is part of the COMM-domain containing protein family, known for its role in various cellular processes including protein regulation, endosomal trafficking, and innate immunity. By utilizing these knockout cell lines, researchers can investigate the specific functional roles of COMMD4 in cellular contexts, including its contributions to disease mechanisms such as cancer and neurodegeneration.

The key mechanism of action involves the targeted editing of the COMMD4 gene through techniques such as CRISPR/Cas9, which allows for precise alterations in the genomic sequence. Researchers can then study the resultant phenotypic changes, shedding light on how the absence of COMMD4 influences cellular function and signaling pathways. This model provides insights into the gene's contributions to cellular homeostasis, protein interactions, and potential implications in disease pathways.

The scientific importance of COMMD4 Gene Knockout Cell Lines lies in their ability to facilitate innovative research into gene function and its implications for human health. These models can be utilized in various applications, from basic research to drug discovery, enabling researchers to explore therapeutic targets and underlying mechanisms of diseases linked to protein dysregulation and immune responses.

COMMD4 knockout models present unique advantages over traditional models, including specificity in gene targeting and the ability to replicate complex biological scenarios found in vivo. This specificity allows for more accurate modeling of human diseases, reducing the potential for off-target effects commonly seen with less precise genetic modification techniques.

For researchers and clinicians focused on gene function studies, these knockout cell lines provide an invaluable tool for advancing our understanding of molecular biology, aiding in the development of targeted therapies. Your investment in COMMD4 Gene Knockout Cell Lines not only enhances your laboratory's capabilities but also positions you at the forefront of innovative research.

As an organization dedicated to advancing scientific discovery, our company brings extensive expertise in genetic engineering technologies and cell line development, ensuring that our products meet the highest standards of quality and reliability for our customers.

Please note that all services are for research use only. Not intended for any clinical use.

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