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COL16A1 Knockout Cell Lines

Gene: COL16A1

Official Full Name: collagen type XVI alpha 1 chainprovided by HGNC

Gene Summary: This gene encodes the alpha chain of type XVI collagen, a member of the FACIT collagen family (fibril-associated collagens with interrupted helices). Members of this collagen family are found in association with fibril-forming collagens such as type I and II, and serve to maintain the integrity of the extracellular matrix. High levels of type XVI collagen have been found in fibroblasts and keratinocytes, and in smooth muscle and amnion. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38481 COL16A1 Knockout cell line (HeLa) Human COL16A1 1:3~1:6 Negative Online Inquiry
KO38482 COL16A1 Knockout cell line (HCT 116) Human COL16A1 1:2~1:4 Negative Online Inquiry
KO38483 COL16A1 Knockout cell line (A549) Human COL16A1 1:3~1:4 Negative Online Inquiry

Background

COL16A1 Gene Knockout Cell Lines are genetically modified cellular models designed to investigate the functional roles of the collagen XVI alpha 1 (COL16A1) gene in various biological processes. This product encapsulates the revolutionary CRISPR-Cas9 genome-editing technology to create stable cellular lines with targeted deletions of the COL16A1 gene, enabling researchers to dissect its contributions to cell adhesion, extracellular matrix integrity, and tissue architecture.

The key function of these knockout cell lines is to provide a platform for studying the impact of the loss of COL16A1 on cellular behavior, signaling pathways, and interactions with surrounding tissues. By eliminating the expression of this gene, researchers can observe changes in cellular morphology, migration, proliferation, and differentiation, thereby elucidating the physiological and pathological roles of COL16A1 in conditions such as fibrosis, cancer, and musculoskeletal disorders.

The scientific importance of COL16A1 Gene Knockout Cell Lines lies in their applicability across various research disciplines, including developmental biology, regenerative medicine, and cancer biology. The insights gleaned from studies utilizing these cell lines can drive the development of therapeutic strategies targeting COL16A1-related pathologies, ultimately benefiting clinical approaches to treatment.

Compared to conventional cell lines or less specific genetic manipulation techniques, COL16A1 Gene Knockout Cell Lines offer precise and reproducible alterations that significantly streamline the research process. Their customization capability allows researchers to tailor experimental designs to their unique needs, yielding high-quality and reliable data.

For researchers and clinicians focused on understanding the complexities of collagen-related functions and their implications in human health, these knockout cell lines represent a valuable tool. They not only facilitate the exploration of cellular processes but also support the validation of potential therapeutic targets.

Our company excels in providing high-quality, rigorously validated biological products designed for cutting-edge research. With a commitment to innovation and scientific advancement, we ensure that every product meets the highest standards, empowering researchers to make meaningful discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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