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CNTN4 Knockout Cell Lines

Gene: CNTN4

Official Full Name: contactin 4provided by HGNC

Gene Summary: This gene encodes a member of the contactin family of immunoglobulins. Contactins are axon-associated cell adhesion molecules that function in neuronal network formation and plasticity. The encoded protein is a glycosylphosphatidylinositol-anchored neuronal membrane protein that may play a role in the formation of axon connections in the developing nervous system. Deletion or mutation of this gene may play a role in 3p deletion syndrome and autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21819 CNTN4 Knockout cell line (HEK293) Human CNTN4 1:3~1:6 Negative Online Inquiry

Background

CNTN4 Gene Knockout Cell Lines are specialized cellular models engineered to lack the contactin 4 (CNTN4) gene, which is integral to neural development and synaptic functioning. These cell lines are invaluable tools that allow researchers to investigate the role of CNTN4 in various biological processes, including neural connectivity, cellular signaling pathways, and implications in neurodevelopmental disorders.

The primary function of CNTN4 is to mediate cell-cell adhesion, thus influencing the formation and maintenance of synapses in the nervous system. By utilizing these knockout cell lines, scientists can elucidate the mechanisms by which CNTN4 contributes to neuronal behavior, specifically how its absence may influence neurodevelopmental disorders such as autism spectrum disorder and schizophrenia, where CNTN4 has been implicated through genetic studies. Furthermore, these models facilitate the exploration of potential therapeutic targets, enabling a deeper understanding of how manipulating CNTN4 expression could lead to innovative treatment strategies.

The scientific importance of CNTN4 Gene Knockout Cell Lines is underscored by their applications in both basic and translational research. Their usage allows for the study of pathway alterations induced by CNTN4 deficiency and the assessment of pharmacological interventions aimed at restoring normal cell function. Compared to traditional cell lines, these knockout models provide a more accurate representation of conditions associated with CNTN4 gene dysregulation, enhancing predictive validity in research findings.

Particularly appealing to researchers and clinicians is the unique selling point of these cell lines: their capacity to offer focused insights into specific genetic contributions to neural function and dysfunction, which is often not achievable with standard or even other genetically modified cell lines. Thus, they stand as a critical resource for advancing our understanding of complex neurological disorders.

Our company possesses a deep expertise in producing high-quality genetic models, allowing us to deliver innovative solutions that enhance research effectiveness. The CNTN4 Gene Knockout Cell Lines exemplify our commitment to empowering scientific discovery and improving clinical outcomes in neurology and beyond.

Please note that all services are for research use only. Not intended for any clinical use.

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