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CNTLN Knockout Cell Lines

Gene: CNTLN

Official Full Name: centleinprovided by HGNC

Gene Summary: Enables protein domain specific binding activity; protein kinase binding activity; and protein-macromolecule adaptor activity. Involved in centriole-centriole cohesion and protein localization to organelle. Located in cytosol; microtubule organizing center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18628 CNTLN Knockout cell line (HeLa) Human CNTLN 1:3~1:6 Negative Online Inquiry
KO18629 CNTLN Knockout cell line (HCT 116) Human CNTLN 1:2~1:4 Negative Online Inquiry
KO18630 CNTLN Knockout cell line (HEK293) Human CNTLN 1:3~1:6 Negative Online Inquiry
KO18631 CNTLN Knockout cell line (A549) Human CNTLN 1:3~1:4 Negative Online Inquiry

Background

CNTLN Gene Knockout Cell Lines are specifically engineered cellular models used for comprehensive functional studies of the CNTLN (Centromere Protein T-like) gene, which plays a crucial role in cellular processes such as chromosomal stability and gene regulation. These cell lines are developed through advanced genetic editing techniques, including CRISPR-Cas9, allowing for precise alterations to the CNTLN gene, enabling researchers to investigate its contribution to various biological phenomena.

The primary function of these knockout cell lines involves elucidating the role of CNTLN in cell cycle regulation, DNA damage response, and signal transduction pathways. Researchers can study the resultant phenotypic changes, such as altered proliferation rates, increased susceptibility to genotoxic stress, and dysregulation of important cellular pathways. This understanding is essential for developing targeted therapies in cancer and other diseases associated with genetic instability.

The scientific importance of CNTLN Gene Knockout Cell Lines extends into both research and clinical settings. In research, these models provide a robust tool for studying gene function, screening for drug responses, and understanding the molecular underpinnings of diseases linked to chromosomal abnormalities. Clinically, insights garnered from these studies may guide therapeutic strategies for conditions like carcinoma, where CNTLN is implicated.

A significant advantage of choosing CNTLN Gene Knockout Cell Lines over conventional models is their high specificity and the ability to directly observe the effects of gene absence in a controlled manner. Furthermore, these cell lines come with rigorous validation and characterization data, ensuring reliability and reproducibility of results, which can be crucial for securing funding and publishing high-impact research.

Researchers and clinicians should consider the CNTLN Gene Knockout Cell Lines as a vital asset in their toolkit for investigating gene function and disease mechanisms. These cell lines not only save time and resources but also provide clarity in understanding complex biological questions.

Our company prides itself on its expertise in providing quality biological products tailored to meet the needs of the scientific community, and the CNTLN Gene Knockout Cell Lines represent our commitment to advancing research through innovative solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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