Gene: CNOT8
Official Full Name: CCR4-NOT transcription complex subunit 8provided by HGNC
Gene Summary: Enables poly(A)-specific ribonuclease activity. Involved in miRNA-mediated gene silencing by mRNA destabilization and positive regulation of cell population proliferation. Located in nucleus. Part of CCR4-NOT complex. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33313 | CNOT8 Knockout cell line (HeLa) | Human | CNOT8 | 1:3~1:6 | Negative | Online Inquiry |
KO33314 | CNOT8 Knockout cell line (HCT 116) | Human | CNOT8 | 1:2~1:4 | Negative | Online Inquiry |
KO33315 | CNOT8 Knockout cell line (HEK293) | Human | CNOT8 | 1:3~1:6 | Negative | Online Inquiry |
KO33316 | CNOT8 Knockout cell line (A549) | Human | CNOT8 | 1:3~1:4 | Negative | Online Inquiry |
CNOT8 Gene Knockout Cell Lines are advanced biological tools designed for the precise study of gene function and regulation. These genetically modified cell lines have undergone targeted gene editing to disrupt the CNOT8 gene, which is known to play a critical role in mRNA decay and post-transcriptional regulation. By utilizing CRISPR/Cas9 or other genome editing technologies, CNOT8 Gene Knockout Cell Lines provide a unique platform for researchers interested in elucidating the molecular pathways governed by the CNOT8 protein and its implications in cellular processes such as apoptosis, proliferation, and response to stress.
The primary function of these knockout cell lines lies in their ability to create a controlled environment where the effects of the absence of CNOT8 can be systematically examined. This can yield crucial insights into gene interactions, cellular signaling pathways, and the overall impact of this gene in various biological contexts. Such detailed mechanistic understanding is invaluable for advancing research in cancer biology, neurobiology, and developmental biology, among other fields.
In comparison to traditional gene knockout methods, CNOT8 Gene Knockout Cell Lines offer significant advantages, including reproducibility, speed, and efficiency in establishing stable cell lines devoid of the target gene. The ready-to-use nature of these cell lines accelerates experimental timelines, allowing researchers to focus on results rather than the complexities of cell line development.
The scientific importance of these cell lines extends into clinical settings as well. With growing evidence linking dysregulation of the CNOT8 gene to various diseases, including certain cancers, these knockout models facilitate the exploration of therapeutic targets and potential gene therapies. Researchers and clinicians alike can utilize these cell lines for drug discovery, biomarker development, and understanding disease mechanisms at a molecular level.
For scientists and researchers seeking reliable and innovative solutions, CNOT8 Gene Knockout Cell Lines represent a powerful asset in the quest for new biological insights and therapeutic advancements. Our company specializes in delivering high-quality biological products that propel research forward, backed by a commitment to innovation and scientific integrity.
Please note that all services are for research use only. Not intended for any clinical use.
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