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CNNM4 Knockout Cell Lines

Gene: CNNM4

Official Full Name: cyclin and CBS domain divalent metal cation transport mediator 4provided by HGNC

Gene Summary: This gene encodes a member of the ancient conserved domain containing protein family. Members of this protein family contain a cyclin box motif and have structural similarity to the cyclins. The encoded protein may play a role in metal ion transport. Mutations in this gene are associated with Jalili syndrome which consists of cone-rod dystrophy and amelogenesis imperfecta. [provided by RefSeq, Feb 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO28077 CNNM4 Knockout cell line (HeLa) Human CNNM4 1:3~1:6 Negative Online Inquiry
KO28078 CNNM4 Knockout cell line (HCT 116) Human CNNM4 1:2~1:4 Negative Online Inquiry
KO28079 CNNM4 Knockout cell line (HEK293) Human CNNM4 1:3~1:6 Negative Online Inquiry
KO28080 CNNM4 Knockout cell line (A549) Human CNNM4 1:3~1:4 Negative Online Inquiry

Background

CNNM4 Gene Knockout Cell Lines are specialized biological reagents that allow researchers to study the function of the CNNM4 gene, which encodes a member of the CNNM family involved in metal ion transport and cellular signaling pathways. These cell lines are engineered through precise genome editing techniques to disrupt the CNNM4 gene, effectively creating a knockout model that provides invaluable insights into the gene's role in various biological processes and diseases.

The primary function of these knockout cell lines is to enable the examination of phenotypic changes resulting from the absence of CNNM4. By employing techniques such as CRISPR-Cas9 technology, researchers can elucidate the consequential pathways influenced by CNNM4 knockout, shedding light on mechanisms tied to cellular ion homeostasis, signaling cascades, and potential implications in pathologies like cancer and neurodegeneration.

Scientifically, CNNM4 Gene Knockout Cell Lines are crucial for basic and applied research, helping to pave the way for novel therapeutic strategies. They serve as a platform for drug discovery and development while also contributing to biomarker identification for diseases associated with ion transport dysregulation. Their availability in clinical studies is paramount, permitting a deeper understanding of disease mechanisms and enhancing the translational potential of therapeutic interventions.

Compared to alternative models, such as plasmid-based overexpression systems or parental cell lines, the specificity and fidelity of knockout cell lines significantly reduce the risk of off-target effects, offering more reliable data. Additionally, these cell lines are ready-to-use, facilitating streamlined experimental design and reducing the time required for researchers to obtain results.

For researchers and clinicians aiming to unravel the complexities of gene function and its implications in health and disease, CNNM4 Gene Knockout Cell Lines represent a robust and precise tool. Developed and manufactured by a company with years of expertise in gene editing technologies and cell line development, this product not only enhances research efficacy but also supports the advancement of scientific knowledge in the field of molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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