Gene: CLXN
Official Full Name: calaxinprovided by HGNC
Gene Summary: Predicted to enable calcium ion binding activity. Predicted to be involved in several processes, including cilium movement; outer dynein arm assembly; and regulation of flagellated sperm motility. Predicted to be located in cilium. Implicated in primary ciliary dyskinesia. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18658 | CLXN Knockout cell line (HEK293) | Human | CLXN | 1:3~1:6 | Negative | Online Inquiry |
CLXN Gene Knockout Cell Lines are specialized human and murine cell lines engineered to have a targeted disruption in the CLXN gene, which encodes the protein Clarin. The knockout of this gene serves as a critical tool for studying cellular mechanisms and gene function, particularly in the context of cell signaling, adhesion, and communication.
These cell lines function by utilizing CRISPR/Cas9 technology to induce specific mutations in the CLXN gene, resulting in a complete loss of function. This precise gene editing mechanism allows researchers to investigate the biological roles of Clarin in various cellular processes such as differentiation, migration, and apoptosis. Additionally, the CLXN knockout models enable the analysis of disease states associated with CLXN dysfunction, such as certain neurological disorders and cancers.
In a research setting, the use of CLXN Gene Knockout Cell Lines is pivotal for elucidating the underlying molecular pathways that rely on Clarin, thus advancing therapeutic strategies. In clinical applications, these cell lines can be employed for drug screening and the development of novel treatment modalities, making them invaluable in both basic and applied biomedical research.
Compared to traditional cell lines, the CLXN knockout variants provide a level of specificity and insight into gene function that is unattainable with less precise models. Their creation optimizes experimental robustness, resulting in reproducible data that can enhance research outcomes while minimizing off-target effects.
For researchers, clinicians, and biotech companies focused on gene regulation and molecular pathways, CLXN Gene Knockout Cell Lines present a unique opportunity to drive innovation. By understanding the critical role of the CLXN gene, users can better navigate the complexities of cellular processes and translate findings into real-world applications.
Our company prides itself on its industry-leading expertise in gene editing and cell line development, ensuring that our products are both scientifically sound and practical for a wide array of research needs. We are committed to advancing the frontiers of biological research with innovative solutions like the CLXN Gene Knockout Cell Lines.
Please note that all services are for research use only. Not intended for any clinical use.
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