Gene: CLPX
Official Full Name: caseinolytic mitochondrial matrix peptidase chaperone subunit Xprovided by HGNC
Gene Summary: The protein encoded by this gene is part of a protease found in mitochondria. This protease is ATP-dependent and targets specific proteins for degradation. The protease consists of two heptameric rings of the CLPP catalytic subunit sandwiched between two hexameric rings of the chaperone subunit encoded by this gene. Targeted proteins are unwound by this protein and then passed on to the CLPP subunit for degradation. Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO02579 | CLPX Knockout cell line (HeLa) | Human | CLPX | 1:3~1:6 | Negative | Online Inquiry |
KO02580 | CLPX Knockout cell line (HCT 116) | Human | CLPX | 1:2~1:4 | Negative | Online Inquiry |
KO02581 | CLPX Knockout cell line (HEK293) | Human | CLPX | 1:3~1:6 | Negative | Online Inquiry |
KO02582 | CLPX Knockout cell line (A549) | Human | CLPX | 1:3~1:4 | Negative | Online Inquiry |
CLPX Gene Knockout Cell Lines are a revolutionary tool in biomedical research, specifically designed for studies involving the CLPX gene, a critical component in mitochondrial protein quality control and cellular stress response mechanisms. These cell lines have been engineered using CRISPR-Cas9 technology to create targeted deletions of the CLPX gene, resulting in a unique model that allows scientists to investigate the physiological and pathological roles of CLPX in various cellular contexts.
The primary function of CLPX Gene Knockout Cell Lines is to elucidate the impact of CLPX deficiency on mitochondrial function, protein homeostasis, and cell survival under stress conditions. When the CLPX gene is knocked out, researchers can observe changes in mitochondrial dynamics, alterations in ATP production, and shifts in the activation of stress response pathways. This Heterologous expression system offers a clear perspective on the gene’s crucial involvement in metabolic processes and its implications in diseases such as neurodegeneration and cancer.
The scientific importance of CLPX Gene Knockout Cell Lines extends to a vast array of applications within research and clinical settings. They provide a vital platform for drug discovery and the testing of therapeutic strategies aimed at restoring mitochondrial function in disease models. Additionally, these cell lines can facilitate the screening of potential genetic modifiers and help to identify novel targets for intervention.
What sets CLPX Gene Knockout Cell Lines apart from alternative products on the market is their specificity and reliability, ensuring reproducible results that can be confidently applied to further research. The precision of CRISPR technology offers remarkable gene editing accuracy, while our robust quality control processes guarantee consistent performance across all batches.
For researchers and clinicians alike, the value of CLPX Gene Knockout Cell Lines lies in their versatility as a research tool that opens new avenues for understanding mitochondrial disorders and developing targeted therapies. By integrating this product into your research, you significantly enhance the potential for groundbreaking findings related to mitochondrial biology and related pathologies.
Our company prides itself on its expertise in genetic engineering and cell line development, backed by a commitment to providing high-quality biological products tailored to meet the needs of the scientific community. The CLPX Gene Knockout Cell Lines embody our dedication to advancing research through cutting-edge technology and reliable, innovative solutions.
Please note that all services are for research use only. Not intended for any clinical use.
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