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CLPB Knockout Cell Lines

Gene: CLPB

Official Full Name: ClpB family mitochondrial disaggregaseprovided by HGNC

Gene Summary: This gene belongs to the ATP-ases associated with diverse cellular activities (AAA+) superfamily. Members of this superfamily form ring-shaped homo-hexamers and have highly conserved ATPase domains that are involved in various processes including DNA replication, protein degradation and reactivation of misfolded proteins. All members of this family hydrolyze ATP through their AAA+ domains and use the energy generated through ATP hydrolysis to exert mechanical force on their substrates. In addition to an AAA+ domain, the protein encoded by this gene contains a C-terminal D2 domain, which is characteristic of the AAA+ subfamily of Caseinolytic peptidases to which this protein belongs. It cooperates with Hsp70 in the disaggregation of protein aggregates. Allelic variants of this gene are associated with 3-methylglutaconic aciduria, which causes cataracts and neutropenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00146 CLPB Knockout cell line (HEK293) Human CLPB 1:3~1:6 Negative Online Inquiry
KO06000 CLPB Knockout cell line (HeLa) Human CLPB 1:3~1:6 Negative Online Inquiry
KO06001 CLPB Knockout cell line (HCT 116) Human CLPB 1:2~1:4 Negative Online Inquiry
KO06002 CLPB Knockout cell line (A549) Human CLPB 1:3~1:4 Negative Online Inquiry

Background

CLPB Gene Knockout Cell Lines are sophisticated research tools specifically designed to facilitate the study of the CLPB gene, which encodes for the mitochondrial ATP-dependent protease ClpB. These cell lines have been engineered to lack the expression of the CLPB gene, enabling scientists to explore its biological role in cellular processes, mitochondrial dynamics, and proteostasis. By utilizing these knockout cell lines, researchers can investigate the consequences of CLPB gene loss on various metabolic pathways, stress responses, and cellular aging mechanisms.

The primary function of CLPB Gene Knockout Cell Lines lies in their ability to model the effects of CLPB gene deletions within a controlled environment. Through an array of experimental assays, these cell lines allow for the assessment of mitochondrial function, protein quality control, and the cellular impact of protein aggregation disorders. The use of CRISPR-Cas9 technology or other targeted gene-editing methods in creating these knockout lines ensures high specificity and efficiency, enabling reproducible results crucial for both basic and applied research.

Scientifically, the applications of CLPB Gene Knockout Cell Lines are extensive, ranging from fundamental studies in cellular biology to the development of therapeutic strategies for diseases linked to mitochondrial dysfunction, such as neurodegenerative disorders. Their significance in clinical research cannot be understated, as insights gained from these models are essential for understanding the pathophysiology of diseases where proteostasis failure is a central feature.

Compared to traditional cell lines, CLPB Gene Knockout Cell Lines offer distinct advantages, including the ability to study gene function without compensatory mechanisms that often confound data interpretation in wild-type models. This specificity makes them exceptional resources for researchers pursuing targeted therapies and molecular insights.

The value of CLPB Gene Knockout Cell Lines extends beyond their scientific applications; they represent a cornerstone for innovation within the biotech industry. With the ever-increasing need for precise and detailed models in research, these cell lines provide an unparalleled opportunity for researchers and clinicians to derive meaningful conclusions that can drive advancements in treatment methodologies.

As a leader in biotechnological advancements, our company is committed to delivering cutting-edge biological products that empower scientific exploration and discovery. Our expertise in developing high-quality genetic models assures our partners of reliable tools that meet their rigorous research demands.

Please note that all services are for research use only. Not intended for any clinical use.

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