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CLINT1 Knockout Cell Lines

Gene: CLINT1

Official Full Name: clathrin interactor 1provided by HGNC

Gene Summary: This gene encodes a protein with similarity to the epsin family of endocytic adapter proteins. The encoded protein interacts with clathrin, the adapter protein AP-1 and phosphoinositides. This protein may be involved in the formation of clathrin coated vesicles and trafficking between the trans-Golgi network and endosomes. Mutations in this gene are associated with a susceptibility to schizophrenia and psychotic disorders. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32923 CLINT1 Knockout cell line (HeLa) Human CLINT1 1:3~1:6 Negative Online Inquiry
KO32924 CLINT1 Knockout cell line (HCT 116) Human CLINT1 1:2~1:4 Negative Online Inquiry
KO32925 CLINT1 Knockout cell line (HEK293) Human CLINT1 1:3~1:6 Negative Online Inquiry
KO32926 CLINT1 Knockout cell line (A549) Human CLINT1 1:3~1:4 Negative Online Inquiry

Background

CLINT1 Gene Knockout Cell Lines are specially engineered cellular models designed to study the role and function of the CLINT1 gene, particularly in cellular trafficking and membrane dynamics. Utilizing state-of-the-art CRISPR/Cas9 gene-editing technology, these cell lines have been meticulously crafted to achieve precise deletion of the CLINT1 gene, allowing researchers to explore its contributions to various biological processes without the influence of the gene's expression.

The primary function of CLINT1, or Clathrin-Interacting Protein 1, is pivotal in endocytosis, a vital cellular process for nutrient uptake and signal transduction. In these knockout cell lines, the absence of CLINT1 enables researchers to elucidate its role in clathrin-mediated endocytosis, revealing insights into membrane invagination and the sorting of intracellular cargo. This knowledge is critical not only for fundamental biological research but also for understanding pathologies that stem from dysfunctional cellular trafficking.

The significance of CLINT1 Gene Knockout Cell Lines extends into both research and clinical applications. In the laboratory, these models are invaluable for investigating the molecular mechanisms underlying numerous diseases, including cancer and neurodegenerative disorders, where altered endosomal pathways are implicated. Moreover, they serve as a robust platform for drug screening, offering opportunities to identify therapeutics that can rectify the cellular dysfunction caused by the absence of CLINT1.

Compared to alternative models, such as wild-type or less specific knockdown cell lines, our CLINT1 Gene Knockout Cell Lines provide a unique advantage by delivering a complete and permanent loss-of-function phenotype for the gene of interest. This specificity enhances the reliability of experimental outcomes, allowing for more accurate interpretations of data and fostering a deeper understanding of gene function.

Researchers and clinicians will find immense value in these knockout cell lines, as they not only enhance experimental rigor but also accelerate the discovery of novel insights into cellular mechanisms. By choosing our CLINT1 Gene Knockout Cell Lines, you invest in a model that embodies precision, efficiency, and enhanced scientific inquiry.

Our company prides itself on its expertise in providing high-quality biological products tailored for advanced research applications. With a proven track record in genetic engineering and a commitment to supporting the scientific community, we ensure that our products meet the highest standards of reliability and functionality, empowering researchers to advance their studies with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

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