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CHKB Knockout Cell Lines

Gene: CHKB

Official Full Name: choline kinase betaprovided by HGNC

Gene Summary: Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by RefSeq, Jun 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38551 CHKB Knockout cell line (HeLa) Human CHKB 1:3~1:6 Negative Online Inquiry
KO38552 CHKB Knockout cell line (HCT 116) Human CHKB 1:2~1:4 Negative Online Inquiry
KO38553 CHKB Knockout cell line (HEK293) Human CHKB 1:3~1:6 Negative Online Inquiry
KO38554 CHKB Knockout cell line (A549) Human CHKB 1:3~1:4 Negative Online Inquiry

Background

CHKB Gene Knockout Cell Lines are genetically engineered mammalian cell lines that have had the CHKB gene selectively disrupted. This innovative product serves as a powerful tool for researchers seeking to understand the biological functions associated with the CHKB gene, which encodes a choline kinase enzyme involved in phospholipid metabolism and cellular signaling pathways. The knockout of this gene enables the investigation of its role in various physiological and pathological contexts, including cancer research, neurological disorders, and metabolic diseases.

These cell lines function by utilizing CRISPR-Cas9 or other gene-editing techniques to create precise deletions in the CHKB gene, resulting in the elimination of its expression. This mechanism allows scientists to directly study the consequences of CHKB loss on cellular behavior, proliferation, and response to external stimuli, enabling deeper insights into the specific signaling cascades influenced by choline metabolism.

The scientific importance of CHKB Gene Knockout Cell Lines is paramount, especially in translational research and drug development. They can provide invaluable information about the potential therapeutic targets within choline metabolism pathways, making them essential tools for both academic and pharmaceutical research settings. They represent a significant advancement over traditional knockout models, as researchers can conduct experiments in a controlled, homogenous cellular environment.

Distinct advantages of our CHKB Gene Knockout Cell Lines include their validated knockout status, reproducibility in experiments, and customizability to suit specific experimental needs. In contrast to other gene editing techniques that may yield variable results or off-target effects, our product provides a reliable foundation for studies that demand precision.

For researchers and clinicians focused on innovative therapeutic development, these cell lines offer a unique opportunity to explore the implications of target gene disruption directly. Understanding the role of the CHKB gene can catalyze breakthroughs in identifying new pathways and targets for intervention in diseases where phospholipid metabolism plays a critical role.

At our company, we pride ourselves on our deep expertise in genetic engineering and our commitment to delivering high-quality biological products. Our CHKB Gene Knockout Cell Lines are developed with rigorous validation processes, ensuring that researchers have access to reliable resources that enhance their scientific investigations.

Please note that all services are for research use only. Not intended for any clinical use.

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