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CGNL1 Knockout Cell Lines

Gene: CGNL1

Official Full Name: cingulin like 1provided by HGNC

Gene Summary: This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Nov 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24404 CGNL1 Knockout cell line (HCT 116) Human CGNL1 1:2~1:4 Negative Online Inquiry
KO24405 CGNL1 Knockout cell line (HEK293) Human CGNL1 1:3~1:6 Negative Online Inquiry
KO24406 CGNL1 Knockout cell line (A549) Human CGNL1 1:3~1:4 Negative Online Inquiry

Background

CGNL1 Gene Knockout Cell Lines are precisely engineered cellular models that lack the expression of the CGNL1 gene, which is implicated in various cellular processes including proliferation, adhesion, and cytoskeletal organization. Through advanced CRISPR-Cas9 gene-editing technology, these knockout cell lines allow researchers to study the functional relevance of CGNL1 in different biological contexts. The disruption of the CGNL1 gene provides significant insights into its contributions to cellular mechanics and disease pathology, making it a valuable tool for understanding its role in conditions such as cancer and neurodegenerative disorders.

The primary function of CGNL1 Gene Knockout Cell Lines is to serve as an experimental platform where the absence of CGNL1 can be correlated with phenotypic changes. Researchers can dissect the mechanisms underlying CGNL1’s involvement in cellular signaling pathways, gene expression regulation, and interactions with other proteins. This enables a comprehensive exploration of the gene’s functions through various approaches, including transcriptomic and proteomic analyses, thereby providing a holistic understanding of the biological processes affected by its knockout.

In the scientific landscape, the applications of these cell lines extend from basic research to clinical implications. In vitro studies using CGNL1 knockouts can elucidate potential therapeutic targets, leading to the development of novel strategies for disease intervention. Additionally, the time-efficient and economical nature of such cell lines makes them ideal for high-throughput screening and drug discovery processes, further enriching their relevance in both academic and pharmaceutical research settings.

Compared to alternative gene knockout models, CGNL1 Gene Knockout Cell Lines stand out due to their specificity and completeness of gene disruption. Utilizing optimally validated techniques ensures consistent results, and the availability of multiple lines tailored for various types of cells enhances their versatility across different experimental conditions. Furthermore, these cell lines come with rigorous quality controls and documentation, offering researchers confidence in reproducibility and reliability.

For researchers and clinicians, the CGNL1 Gene Knockout Cell Lines represent a formidable asset, empowering them to deeply investigate the unknown, enabling novel insights into gene function, and providing pathways to pioneering therapies. By integrating cutting-edge genome editing technology with robust cellular architecture, this product positions itself as a premier choice for those seeking to advance their scientific inquiries.

Our company specializes in providing high-quality biological tools, and our expertise in gene-editing technologies ensures that the CGNL1 Gene Knockout Cell Lines meet the highest standards, making them an indispensable resource in today’s research environment.

Please note that all services are for research use only. Not intended for any clinical use.

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