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CFL2 Knockout Cell Lines

Gene: CFL2

Official Full Name: cofilin 2provided by HGNC

Gene Summary: This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38585 CFL2 Knockout cell line (HeLa) Human CFL2 1:3~1:6 Negative Online Inquiry
KO38586 CFL2 Knockout cell line (HCT 116) Human CFL2 1:2~1:4 Negative Online Inquiry
KO38587 CFL2 Knockout cell line (HEK293) Human CFL2 1:3~1:6 Negative Online Inquiry
KO38588 CFL2 Knockout cell line (A549) Human CFL2 1:3~1:4 Negative Online Inquiry

Background

CFL2 Gene Knockout Cell Lines are genetically modified cell lines in which the CFL2 gene has been disrupted to study its functional role in various biological processes. These cell lines serve as a crucial tool for researchers investigating the effects of CFL2 knockdown on cytoskeletal dynamics, cellular signaling pathways, and cell proliferation. The knockout mechanism typically involves the use of CRISPR-Cas9 or other genome-editing techniques, resulting in the complete absence of CFL2 expression, thereby allowing for detailed functional analysis.

The key functions of CFL2 are linked to the regulation of actin filament dynamics, which are essential for maintaining cell shape, motility, and division. By utilizing CFL2 Gene Knockout Cell Lines, scientists can systematically examine the implications of CFL2 deficiency on cellular architecture and behavior, including changes in morphology, migration, and apoptosis. This can provide valuable insights into the pathogenesis of various diseases, including cancer and other disorders attributed to cytoskeletal dysfunction.

Scientifically, these knockout cell lines are significant in both research and clinical applications, serving as a model for drug screening, gene therapy, and understanding disease mechanisms. Compared to alternatives such as knockdown models using RNA interference, knockout cell lines offer a more permanent solution to elucidate gene function, providing definitive results regarding the absence of the targeted gene.

The unique selling points of CFL2 Gene Knockout Cell Lines include their high specificity, reproducibility, and ability to mimic in vivo conditions more accurately compared to transient knockdown approaches. This makes them an invaluable resource for researchers, providing a reliable platform for experimentations that require a stable genetic background.

For researchers and clinicians aiming to unlock the secrets of cell biology and disease, CFL2 Gene Knockout Cell Lines represent an unparalleled asset, facilitating the advancement of scientific knowledge and therapeutic development. Our company specializes in delivering high-quality biological products, and our expertise ensures that you receive well-characterized cell lines that meet the rigorous demands of modern research.

Please note that all services are for research use only. Not intended for any clinical use.

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