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CFAP44 Knockout Cell Lines

Gene: CFAP44

Official Full Name: cilia and flagella associated protein 44provided by HGNC

Gene Summary: Enables peptidase activity. Involved in sperm axoneme assembly. Acts upstream of or within microtubule cytoskeleton organization. Predicted to be located in cytoplasm; cytoskeleton; and motile cilium. Implicated in spermatogenic failure 20. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18793 CFAP44 Knockout cell line (HeLa) Human CFAP44 1:3~1:6 Negative Online Inquiry
KO18794 CFAP44 Knockout cell line (HCT 116) Human CFAP44 1:2~1:4 Negative Online Inquiry
KO18795 CFAP44 Knockout cell line (HEK293) Human CFAP44 1:3~1:6 Negative Online Inquiry
KO18796 CFAP44 Knockout cell line (A549) Human CFAP44 1:3~1:4 Negative Online Inquiry

Background

CFAP44 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to study the function and implications of the CFAP44 gene in various biological processes. These cell lines are generated using advanced CRISPR-Cas9 technology, which facilitates precise gene editing to create definitive knockouts, enhancing insights into gene function by abrogating its expression. The CFAP44 gene has been implicated in key cellular activities, including ciliary structure maintenance and motility, making these cell lines invaluable for research into related pathologies, such as respiratory diseases and spermatogenic defects.

The primary function of the CFAP44 knockout cell lines lies in their ability to serve as a controlled environment to investigate the downstream effects of CFAP44 depletion. Researchers can utilize these models to explore alterations in cellular signaling pathways, morphology, and motility, enabling a comprehensive understanding of the associated physiological processes. Their use within experimental setups can elucidate the role of CFAP44 in various disease models, making them crucial for both basic and applied research.

In clinical settings, CFAP44 knockout cell lines are instrumental for drug screening and therapeutic development, particularly for diseases linked to ciliary dysfunction. Compared to alternative cell lines, which may exhibit residual CFAP44 activity leading to inconsistent results, our knockout cell lines provide a pure and definitive model for mechanistic studies.

Researchers and clinicians benefit significantly from utilizing CFAP44 knockout cell lines due to their specificity, reproducibility, and the depth of insight they can provide into genetic functions and pathology correlation. Furthermore, these cell lines facilitate the exploration of potential therapeutic targets and biomarker identification, such as diagnostic tools for ciliary diseases.

Our company specializes in high-quality, customizable cell lines developed through cutting-edge gene editing technologies, ensuring that researchers have access to reliable and effective tools for their inquiries into gene function and therapeutics. This expertise underpins our commitment to advancing biomedical research and enhancing scientific discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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