Gene: CFAP418
Official Full Name: cilia and flagella associated protein 418provided by HGNC
Gene Summary: This gene encodes a ubiquitously expressed protein of unknown function. It has high levels of mRNA expression in the brain, heart, and retina and the protein co-localizes with polyglutamylated tubulin at the base of the primary cilium in human retinal pigment epithelial cells. Mutations in this gene have been associated with autosomal recessive cone-rod dystrophy (arCRD) and retinitis pigmentosa (arRP). [provided by RefSeq, Mar 2012]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18763 | CFAP418 Knockout cell line (HeLa) | Human | CFAP418 | 1:3~1:6 | Negative | Online Inquiry |
KO18764 | CFAP418 Knockout cell line (HCT 116) | Human | CFAP418 | 1:2~1:4 | Negative | Online Inquiry |
KO18765 | CFAP418 Knockout cell line (HEK293) | Human | CFAP418 | 1:3~1:6 | Negative | Online Inquiry |
KO18766 | CFAP418 Knockout cell line (A549) | Human | CFAP418 | 1:3~1:4 | Negative | Online Inquiry |
CFAP418 Gene Knockout Cell Lines are genetically modified cell lines in which the CFAP418 gene has been specifically targeted and disrupted using CRISPR-Cas9 technology. This powerful tool enables precise alterations to the genomic DNA, facilitating the study of gene function and regulation. In the case of CFAP418, knockout cell lines provide researchers with invaluable resources to explore the biological role of this gene, particularly in the context of ciliary function and related cellular processes.
The primary function of CFAP418 is associated with the structure and dynamics of the cilia, which play critical roles in various signaling pathways and cellular motility. By generating a CFAP418 knockout, researchers can investigate the downstream effects on ciliary assembly, maintenance, and associated signaling mechanisms. This enables a deeper understanding of the pathophysiology underlying ciliopathies and other disorders related to ciliary dysfunction.
The scientific importance of CFAP418 Gene Knockout Cell Lines extends to both basic and applied research. In clinical settings, these cell lines may be pivotal for elucidating the molecular pathways involved in ciliary-related diseases, which can lead to novel therapeutic strategies. Furthermore, these cell lines serve as a foundation for drug screening and genetic studies to discover new biomarkers for disease.
Compared to alternative models, such as transient knockdown or wild-type cell lines, our CFAP418 knockout models provide stable and reproducible results across experiments, ensuring reliability in data collection. Their robustness allows for long-term studies that are vital in understanding the implications of CFAP418 deficiency.
For researchers and clinicians focusing on genetic regulation, cellular biology, or translational medicine, CFAP418 Gene Knockout Cell Lines represent a powerful asset in the quest to uncover new insights into health and disease. Our company is dedicated to providing high-quality biological products, backed by extensive expertise in gene editing technologies, ensuring that our customers have access to the most reliable and innovative research tools available.
Please note that all services are for research use only. Not intended for any clinical use.
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