Gene: CES4A
Official Full Name: carboxylesterase 4Aprovided by HGNC
Gene Summary: This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO18797 | CES4A Knockout cell line (HeLa) | Human | CES4A | 1:3~1:6 | Negative | Online Inquiry |
KO18798 | CES4A Knockout cell line (A549) | Human | CES4A | 1:3~1:4 | Negative | Online Inquiry |
CES4A Gene Knockout Cell Lines are specialized cellular models engineered to lack the CES4A gene, which encodes for a crucial enzyme involved in various metabolic pathways. These cell lines serve as powerful tools in molecular and cellular biology, enabling researchers to study the functional role of CES4A in diverse biological processes, such as drug metabolism, cell signaling, and disease pathology.
The key function of CES4A Gene Knockout Cell Lines lies in their ability to elucidate the contributions of the CES4A enzyme to physiological and pathological states. By utilizing CRISPR-Cas9 technology, these cell lines are generated with precise gene editing, providing a clean and effective knockdown mechanism. Researchers can assess the resultant phenotypic changes, gene expression profiles, and alterations in metabolic activities, thus advancing our understanding of CES4A's function in health and disease.
In scientific settings, these knockout cell lines are essential for drug discovery and development, facilitating the identification of CES4A's role in pharmacokinetics and toxicity. They are pivotal in studying various diseases, including cancers and metabolic disorders, offering insights that could lead to innovative therapeutic targets or biomarkers.
What sets CES4A Gene Knockout Cell Lines apart from alternative models is their high specificity and reproducibility, ensuring reliable experimental outcomes. Unlike generalized cell lines which may exhibit off-target effects, our knockout models provide a focused approach to studying CES4A-related pathways without background interference.
These cell lines are a valuable resource for researchers and clinicians aiming to expand their knowledge of metabolic processes and therapeutic interventions. Their ability to streamline experimental protocols and enhance data accuracy makes them an indispensable addition to any laboratory focused on translational science.
Our company specializes in providing high-quality biological products, leveraging cutting-edge genetic engineering technologies to meet the needs of researchers in both academia and industry. With a commitment to excellence, we ensure that our CES4A Gene Knockout Cell Lines support innovative research and contribute significantly to advancements in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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