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CERT1 Knockout Cell Lines

Gene: CERT1

Official Full Name: ceramide transporter 1provided by HGNC

Gene Summary: This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO02032 CERT1 Knockout cell line (HeLa) Human CERT1 1:3~1:6 Negative Online Inquiry
KO02033 CERT1 Knockout cell line (HCT 116) Human CERT1 1:2~1:4 Negative Online Inquiry
KO02034 CERT1 Knockout cell line (HEK293) Human CERT1 1:3~1:6 Negative Online Inquiry
KO02035 CERT1 Knockout cell line (A549) Human CERT1 1:3~1:4 Negative Online Inquiry

Background

CERT1 Gene Knockout Cell Lines represent an innovative tool in the field of molecular biology and genetics, specifically designed to elucidate the functions of the CERT1 gene. These cell lines are engineered to possess a disruption or knockout of the CERT1 gene, allowing researchers to investigate the resultant phenotypic changes and cellular mechanisms in a controlled environment. By negating the expression of CERT1, scientists can observe the impacts on lipid metabolism, cell signaling pathways, and overall cellular health, thereby enhancing our understanding of various physiological and pathological processes.

The key function of CERT1 is its involvement in the regulation of ceramide transport within cells, which plays a significant role in lipid metabolism and cellular signaling. The knockout of this gene alters the intracellular dynamics of lipid distribution, leading to a series of downstream effects that can be studied in vitro. This tool is essential for researchers exploring the roles of lipid mediators in diseases like obesity, diabetes, and certain cancers, making it invaluable in both basic and applied biomedical research.

Scientifically, CERT1 Gene Knockout Cell Lines hold significant potential in translational research and drug development settings. By employing these cell lines, scientists can conduct high-throughput screening for novel therapeutic agents that target lipid metabolism pathways. In addition, these models can facilitate the development of gene therapies aimed at correcting lipid metabolomic disorders associated with CERT1 dysfunction.

Compared to traditional overexpression models or chemical inhibitors, the CERT1 Gene Knockout Cell Lines provide a more precise method for dissecting the role of this gene within the complex milieu of cellular interactions. This specificity allows researchers to generate reliable data that better reflects physiological conditions as opposed to artificially manipulated systems, thereby leading to an enhanced understanding of the underlying biology.

For researchers and clinicians alike, the value of CERT1 Gene Knockout Cell Lines lies not only in the insights they provide into the CERT1 gene's role but also in their utility as a platform for novel therapeutic discovery. Our company, recognized for its cutting-edge advancements in genetic engineering, is dedicated to supporting the scientific community by offering high-quality, validated cell lines that empower researchers to push the boundaries of biomedical science.

Please note that all services are for research use only. Not intended for any clinical use.

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