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CEP164 Knockout Cell Lines

Gene: CEP164

Official Full Name: centrosomal protein 164provided by HGNC

Gene Summary: This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO30142 CEP164 Knockout cell line (HeLa) Human CEP164 1:3~1:6 Negative Online Inquiry
KO30143 CEP164 Knockout cell line (HCT 116) Human CEP164 1:2~1:4 Negative Online Inquiry
KO30144 CEP164 Knockout cell line (HEK293) Human CEP164 1:3~1:6 Negative Online Inquiry
KO30145 CEP164 Knockout cell line (A549) Human CEP164 1:3~1:4 Negative Online Inquiry

Background

CEP164 Gene Knockout Cell Lines are genetically modified cell lines that have been specifically engineered to lack the CEP164 gene, which encodes a protein that plays a crucial role in centrosome integrity and cellular function. These cell lines serve as invaluable tools for studying the biological functions of CEP164 and its implications in cell division, cancer progression, and other diseases. By providing a model that mimics the loss of CEP164, researchers can investigate the resultant phenotypic changes, gaining insight into pathways involved in cellular proliferation and signaling networks.

The core mechanism of these knockout cell lines revolves around the complete removal or disruption of the CEP164 gene, which subsequently affects the centrosome's architecture and functionality. This genetic alteration results in a variety of phenotypic consequences, including altered mitotic integrity and enhanced susceptibility to stress conditions. Such insights are essential for understanding the role of CEP164 in human health and disease.

In terms of scientific significance, CEP164 Gene Knockout Cell Lines are particularly valuable in research settings focused on cancer biology, developmental biology, and cell cycle regulation. They are instrumental in elucidating gene function, validating therapeutic targets, and screening for potential drug candidates in preclinical studies. The precise modulation of gene expression in these tailored cell models allows for insights that could inform treatment strategies and increase our understanding of disease mechanisms.

Compared to other gene knockout models, the CEP164 Cell Lines offer a unique and optimized approach with high consistency and reproducibility, ensuring reliable data for downstream assays and experiments. Their use can significantly streamline research workflows and enhance data quality, positioning them as a standout choice in the rapidly evolving landscape of genetic research tools.

For researchers and clinicians, the availability of CEP164 Gene Knockout Cell Lines represents not just a product, but an opportunity to advance knowledge and innovation within their respective fields. By utilizing these advanced cell models, users can expect to achieve unprecedented insights into the biological significance of the CEP164 protein.

Our company is committed to delivering high-quality biological research tools, backed by robust scientific expertise and a dedication to supporting breakthroughs in life sciences. We strive to empower researchers with cutting-edge products that drive discovery and enhance the potential for pioneering therapeutic solutions.

Please note that all services are for research use only. Not intended for any clinical use.

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