Home / CENPU Knockout Cell Lines

CENPU Knockout Cell Lines

Gene: CENPU

Official Full Name: centromere protein Uprovided by HGNC

Gene Summary: The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). MLF1IP, or CENPU, is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18827 CENPU Knockout cell line (HeLa) Human CENPU 1:3~1:6 Negative Online Inquiry
KO18828 CENPU Knockout cell line (HCT 116) Human CENPU 1:2~1:4 Negative Online Inquiry
KO18829 CENPU Knockout cell line (HEK293) Human CENPU 1:3~1:6 Negative Online Inquiry
KO18830 CENPU Knockout cell line (A549) Human CENPU 1:3~1:4 Negative Online Inquiry

Background

CENPU Gene Knockout Cell Lines are specialized cellular models engineered to facilitate comprehensive studies on the CENPU gene, which plays a pivotal role in centromere function and chromosome segregation during cell division. These cell lines are created using advanced CRISPR/Cas9 gene editing technology, enabling the precise deletion of the CENPU gene, thus allowing researchers to investigate its biological significance in a controlled environment.

The primary function of CENPU Gene Knockout Cell Lines is to provide insights into the molecular mechanisms underpinning chromosome behavior and stability. By observing these knockout cells, researchers can elucidate the role CENPU plays in mitotic processes and explore the consequences of its deficiency, such as aneuploidy or impaired cell division. This knowledge is critical for understanding various diseases, including cancer, where centromere dysfunction is a notable feature.

In both research and clinical settings, these cell lines are invaluable tools for drug development, genetic studies, and cellular biology investigations. Their applications span from assessing the effects of pharmacological agents on cell proliferation and viability to serving as platforms for gene therapy approaches or novel genetic interventions.

What sets CENPU Gene Knockout Cell Lines apart from other cellular models is their specificity and efficacy. Unlike traditional cell lines, these knockout models offer a more accurate reflection of how CENPU mutations can impact cellular behavior, minimizing background noise from other genetic variables. This specificity ensures more reproducible results and better translational potential.

For researchers and clinicians, the availability of these cell lines represents an opportunity to deepen their understanding of cell division and its implications in human health and disease. The ability to study the direct effects of CENPU loss provides critical insights that could lead to innovative therapeutic strategies and interventions.

Our company prides itself on delivering high-quality biological products, backed by years of scientific expertise and innovation. With CENPU Gene Knockout Cell Lines, we strive to empower the scientific community with the tools necessary for groundbreaking research and discovery.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.