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CENPQ Knockout Cell Lines

Gene: CENPQ

Official Full Name: centromere protein Qprovided by HGNC

Gene Summary: CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18831 CENPQ Knockout cell line (HeLa) Human CENPQ 1:3~1:6 Negative Online Inquiry
KO18832 CENPQ Knockout cell line (HCT 116) Human CENPQ 1:2~1:4 Negative Online Inquiry
KO18833 CENPQ Knockout cell line (HEK293) Human CENPQ 1:3~1:6 Negative Online Inquiry
KO18834 CENPQ Knockout cell line (A549) Human CENPQ 1:3~1:4 Negative Online Inquiry

Background

CENPQ Gene Knockout Cell Lines are genetically modified cellular systems specifically designed to study the roles of the CENPQ gene, which is implicated in cellular processes such as centromere function and chromosomal stability. These cell lines feature precise gene knockouts achieved through CRISPR/Cas9 technology, leading to the complete ablation of the CENPQ gene's expression. This powerful method enables researchers to examine the resultant phenotypic changes and understand the implications of CENPQ deficiency in various biological contexts.

The key functions of CENPQ Gene Knockout Cell Lines lie in their ability to elucidate the molecular mechanisms underlying cell division and genome integrity. By investigating these cell lines, scientists can determine the consequences of CENPQ absence on centromere formation, checkpoint fidelity, and overall cellular proliferation. Furthermore, the unique genetic background of these cell lines allows for comparative studies across different experimental setups, enhancing the reproducibility and consistency of results.

The scientific importance of CENPQ Gene Knockout Cell Lines extends to both basic research and clinical applications. They serve as indispensable tools for oncologists seeking to understand cancer cell biology, as aberrations in centromere function are frequently associated with tumorigenesis. Additionally, these cell lines can pave the way for the development of targeted therapies aiming to correct or compensate for CENPQ-associated defects.

Compared to typical gene editing tools, CENPQ Gene Knockout Cell Lines offer a streamlined approach, eliminating the need for extensive optimization while guaranteeing high-efficiency gene disruption and cellular model robustness. This product stands out in its specificity, enabling researchers to bypass the confounding effects often seen with less-targeted methods.

The value that CENPQ Gene Knockout Cell Lines bring to researchers, clinicians, and drug developers lies in their ability to provide precise insights into gene function, thereby driving forward the frontiers of biomedical research and therapeutic interventions. Their use can result in enhanced understanding of genetic diseases and potentially lead to more effective treatments.

Our company specializes in the development and supply of innovative biological tools, underpinned by a strong commitment to advancing research capabilities. With expertise in gene editing technologies and a comprehensive portfolio of biological products, we continue to empower scientists in their quest to unlock the mysteries of cellular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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