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CENPP Knockout Cell Lines

Gene: CENPP

Official Full Name: centromere protein Pprovided by HGNC

Gene Summary: CENPP is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO21349 CENPP Knockout cell line (HeLa) Human CENPP 1:3~1:6 Negative Online Inquiry
KO21350 CENPP Knockout cell line (HCT 116) Human CENPP 1:2~1:4 Negative Online Inquiry
KO21351 CENPP Knockout cell line (HEK293) Human CENPP 1:3~1:6 Negative Online Inquiry

Background

CENPP Gene Knockout Cell Lines represent a cutting-edge advancement in genetic research, providing researchers with invaluable tools for investigating the function of the CENPP gene within diverse biological systems. These cell lines have been specifically engineered to induce a disruption of the CENPP gene, allowing for an in-depth analysis of its role in centromere function, chromosomal stability, and cellular processes such as mitosis and DNA repair.

The primary function of the CENPP Gene Knockout Cell Lines involves the targeted inactivation of the CENPP gene through CRISPR-Cas9 technology, ensuring precise genome editing. This method allows researchers to observe phenotypic changes and elucidate the gene's contribution to cellular pathways. By creating conditions that mimic gene loss-of-function scenarios, the cell lines serve as an effective model for studying diseases linked to chromosomal dysfunction, including certain cancers and genetic disorders.

The scientific importance of these cell lines cannot be overstated, as they facilitate groundbreaking research in areas such as cancer biology, genetic regulation, and developmental biology. Their applicability extends from basic research to clinical settings, where understanding the role of CENPP could inform therapeutic strategies or preventative measures for diseases tied to genetic anomalies.

Distinct from conventional cell models, CENPP Gene Knockout Cell Lines offer unique advantages including high specificity of the knockout, reproducibility, and the potential for high-throughput assays. Researchers benefit from a reliable platform to validate their hypotheses with minimal background interference.

For researchers, clinicians, and drug developers, the value of CENPP Gene Knockout Cell Lines lies in their ability to accelerate discovery and innovation. By providing a rigorous investigative framework, these cell lines enhance the understanding of gene function and the implications of chromosomal stability in health and disease.

At our company, we pride ourselves on our expertise in the development and supply of high-quality biological products, ensuring that our customers are equipped with the best tools for advancing their scientific endeavors. Our commitment to innovation and quality positions us as a leader in the field, empowering researchers to push the boundaries of knowledge.

Please note that all services are for research use only. Not intended for any clinical use.

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