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CENPO Knockout Cell Lines

Gene: CENPO

Official Full Name: centromere protein Oprovided by HGNC

Gene Summary: This gene encodes a component of the interphase centromere complex. The encoded protein is localized to the centromere throughout the cell cycle and is required for bipolar spindle assembly, chromosome segregation and checkpoint signaling during mitosis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO18835 CENPO Knockout cell line (HeLa) Human CENPO 1:3~1:6 Negative Online Inquiry
KO18836 CENPO Knockout cell line (HCT 116) Human CENPO 1:2~1:4 Negative Online Inquiry
KO18837 CENPO Knockout cell line (HEK293) Human CENPO 1:3~1:6 Negative Online Inquiry
KO18838 CENPO Knockout cell line (A549) Human CENPO 1:3~1:4 Negative Online Inquiry

Background

CENPO Gene Knockout Cell Lines are specifically engineered cellular models designed to investigate the functional implications of the CENPO gene, which is critical for chromosome stability and proper mitotic progression. These knockout cell lines are generated using advanced CRISPR-Cas9 technology, which allows for precise excision of the CENPO gene, thereby facilitating the study of its role in cellular processes such as cell division, DNA repair, and response to various stressors.

The key mechanism behind these cell lines lies in their ability to mimic conditions of gene loss, providing researchers with a powerful tool to observe the biological consequences of CENPO disruption. By employing these knockout models, scientists can elucidate the signaling pathways and molecular interactions influenced by CENPO, aiding in the broader understanding of cellular mechanics and disease pathology, particularly in cancer and genetic disorders.

In terms of scientific importance, CENPO Gene Knockout Cell Lines play a crucial role in both basic and applied research. Their applications extend to drug discovery, where they can be utilized to assess the efficacy of therapeutic compounds targeting mitotic pathways. Additionally, these cell lines are invaluable in clinical settings, enabling researchers to identify potential biomarkers for diseases related to chromosomal instabilities, ultimately leading to improved diagnostic and therapeutic strategies.

What sets CENPO Gene Knockout Cell Lines apart from alternative models is their reliability and reproducibility, coupled with the industry-leading quality assurance protocols undertaken during their development. Researchers benefit from using these cell lines as they provide a consistently stable background for experimental analysis, minimizing the variability often encountered with other knockout approaches.

The value proposition for researchers and clinicians lies in the unique opportunity to conduct in-depth studies on the CENPO gene's function and its association with critical cellular processes. Our extensive expertise in genetic engineering and robust product offerings ensures that our customers have access to the most advanced tools necessary to push the boundaries of scientific inquiry.

Please note that all services are for research use only. Not intended for any clinical use.

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