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CEMIP2 Knockout Cell Lines

Gene: CEMIP2

Official Full Name: cell migration inducing hyaluronidase 2provided by HGNC

Gene Summary: This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO04043 CEMIP2 Knockout cell line (HeLa) Human CEMIP2 1:3~1:6 Negative Online Inquiry
KO04044 CEMIP2 Knockout cell line (HCT 116) Human CEMIP2 1:2~1:4 Negative Online Inquiry
KO04045 CEMIP2 Knockout cell line (HEK293) Human CEMIP2 1:3~1:6 Negative Online Inquiry
KO04046 CEMIP2 Knockout cell line (A549) Human CEMIP2 1:3~1:4 Negative Online Inquiry

Background

CEMIP2 Gene Knockout Cell Lines are tailored cellular models engineered to facilitate the detailed study of the CEMIP2 (Carboxymethyl Inositol Phosphatase 2) gene's role in cellular processes. These knockout cell lines are meticulously developed using CRISPR-Cas9 technology, which allows for precise gene editing to create cells lacking the functional CEMIP2 gene. By eliminating this gene, researchers can investigate the resultant phenotypic changes and unravel CEMIP2’s involvement in various biological pathways, especially those related to cellular metabolism, proliferation, and tissue-specific responses.

The key function of these knockout cell lines lies in their ability to provide a controlled environment where the specific effects of CEMIP2 absence can be studied rigorously. This facilitates a deeper understanding of its biological mechanisms and the molecular dialogue within cancer biology, neurobiology, and metabolic disorders. As a result, these cell lines serve as invaluable tools for drug discovery, biomarker identification, and the investigation of disease pathways that might be influenced by CEMIP2 activity.

What sets CEMIP2 Gene Knockout Cell Lines apart from alternative models, such as wild-type or non-specific knockdown cell lines, is their enhanced specificity and reliability in experimental outcomes. The precise elimination of the CEMIP2 gene reduces experimental variability often associated with partial gene inhibition, thereby yielding clearer and more interpretable data.

For researchers and clinicians focused on understanding the complexities of diseases linked to CEMIP2, these cell lines offer a cutting-edge resource that can expedite projects aiming for innovative therapeutic interventions. With both scientific rigor and practical applications, CEMIP2 Gene Knockout Cell Lines stand as a cornerstone in advancing biological research.

Our company is dedicated to providing high-quality biological research products, and our expertise in gene editing technologies ensures that our offerings, including the CEMIP2 Gene Knockout Cell Lines, meet the highest standards of scientific excellence and reliability.

Please note that all services are for research use only. Not intended for any clinical use.

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