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CELSR2 Knockout Cell Lines

Gene: CELSR2

Official Full Name: cadherin EGF LAG seven-pass G-type receptor 2provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38090 CELSR2 Knockout cell line (HeLa) Human CELSR2 1:3~1:6 Negative Online Inquiry
KO38091 CELSR2 Knockout cell line (HCT 116) Human CELSR2 1:2~1:4 Negative Online Inquiry
KO38092 CELSR2 Knockout cell line (HEK293) Human CELSR2 1:3~1:6 Negative Online Inquiry
KO38093 CELSR2 Knockout cell line (A549) Human CELSR2 1:3~1:4 Negative Online Inquiry

Background

CELSR2 Gene Knockout Cell Lines are specialized biological tools designed to facilitate the study of the CELSR2 gene, a critical component in the regulation of cellular processes, including cell adhesion and communication during embryonic development. These cell lines have been generated using advanced CRISPR-Cas9 gene editing technology, resulting in a precise deletion of the CELSR2 gene. The knockout of this gene allows researchers to investigate its biological role and the implications of its disruption in various physiological and pathological contexts.

The primary mechanism of these CELSR2 Gene Knockout Cell Lines lies in their ability to elucidate the functional impact of CELSR2 deficiency. By comparing knockout cells with wild-type counterparts, researchers can assess alterations in signaling pathways, cellular morphology, and gene expression profiles. This model is particularly valuable in studying conditions such as neurodevelopmental disorders, where CELSR2 is believed to play a pivotal role, as well as its impact on cancer biology and metastasis.

The scientific importance of CELSR2 Gene Knockout Cell Lines cannot be overstated, as they provide a robust platform for drug discovery and biomarker identification. In clinical settings, these models offer insights into therapeutic targets for diseases linked to structural and functional aberrations in cellular adhesion mechanisms. Unlike alternative genetic manipulation approaches, these knockout lines offer precise, stable modifications without off-target effects, thereby enhancing the reliability of experimental outcomes.

Researchers and clinicians alike will find immense value in the unique selling points of our CELSR2 Gene Knockout Cell Lines. These include rigorously validated performance, consistent quality assurance, and user-friendly protocols that facilitate quick adaptation in various laboratory environments. The high level of precision in gene editing ensures that researchers spend less time troubleshooting and more time focusing on producing impactful results.

In addition to our cutting-edge products, our company brings years of expertise in the biological research field, with a commitment to advancing life sciences through high-quality genetic models. We are dedicated to providing tools that empower scientists to unlock new discoveries in genetics and molecular biology.

Please note that all services are for research use only. Not intended for any clinical use.

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