Gene: CDKN2AIP
Official Full Name: CDKN2A interacting proteinprovided by HGNC
Gene Summary: The protein encoded by this gene regulates the DNA damage response through several different signaling pathways. One such pathway is the p53-HDM2-p21(WAF1) pathway, which is critical to the DNA damage response. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO20810 | CDKN2AIP Knockout cell line (HeLa) | Human | CDKN2AIP | 1:3~1:6 | Negative | Online Inquiry |
KO20811 | CDKN2AIP Knockout cell line (HCT 116) | Human | CDKN2AIP | 1:2~1:4 | Negative | Online Inquiry |
KO20812 | CDKN2AIP Knockout cell line (HEK293) | Human | CDKN2AIP | 1:3~1:6 | Negative | Online Inquiry |
KO20813 | CDKN2AIP Knockout cell line (A549) | Human | CDKN2AIP | 1:3~1:4 | Negative | Online Inquiry |
CDKN2AIP Gene Knockout Cell Lines represent a cutting-edge tool in the realm of molecular biology and genetics research. These cell lines are engineered specifically to have a targeted knockout of the CDKN2AIP gene, which encodes a protein implicated in cell cycle regulation and tumor suppression. By eliminating the expression of this gene, researchers can gain insight into its functional role in cellular processes, particularly in the context of cancer biology.
The mechanism behind the CDKN2AIP knockout involves sophisticated genome editing techniques, such as CRISPR/Cas9 or RNA interference, ensuring precise modification of the gene of interest. This allows scientists to study the downstream effects on cell proliferation, apoptosis, and various signaling pathways directly associated with neoplastic changes. The ability to manipulate gene expression in a controlled manner provides invaluable data that can be utilized to develop novel therapeutic strategies or identify biomarkers for disease progression.
From a scientific perspective, these knockout cell lines hold significant importance in both research and clinical settings. They are indispensable for studying the pathogenesis of malignancies, understanding resistance mechanisms to therapies, and evaluating the effects of potential drugs in a controlled environment. Clinicians and researchers benefit from the availability of standardized models that help bridge the gap between basic research and clinical application.
What sets the CDKN2AIP Gene Knockout Cell Lines apart from other models is their superior specificity and reliability. These lines enable reproducible results across different experiments, thereby enhancing the validity of findings. Moreover, they offer a unique platform for investigating the therapeutic potential of targeting the CDKN2AIP pathway in cancer treatment.
For researchers, clinicians, and pharmaceutical companies, the value of these products lies in their potential to accelerate the discovery of effective therapies while minimizing time and resource expenditure in experimental setups. By leveraging our expertise in gene editing technologies, our company is committed to providing innovative biological products that address the evolving needs of the scientific community, helping to pave the way toward breakthrough solutions in healthcare and disease management.
Please note that all services are for research use only. Not intended for any clinical use.
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